Longitudinal liver stiffness assessment in patients with chronic hepatitis C undergoing antiviral therapy

Liver stiffness (LS) measurement by means of transient elastography (TE) is accurate to predict fibrosis stage. The effect of antiviral treatment and virologic response on LS was assessed and compared with untreated patients with chronic hepatitis C (CHC). TE was performed at baseline, and at weeks...

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Bibliographic Details
Published in:PloS one 2012-10, Vol.7 (10), p.e47715-e47715
Main Authors: Martinez, Stella M, Foucher, Juliette, Combis, Jean-Marc, Métivier, Sophie, Brunetto, Maurizia, Capron, Dominique, Bourlière, Marc, Bronowicki, Jean-Pierre, Dao, Thong, Maynard-Muet, Marianne, Lucidarme, Damien, Merrouche, Wassil, Forns, Xavier, de Lédinghen, Victor
Format: Article
Language:English
Subjects:
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biology
Blood
Care and treatment
Clinical medicine
Elasticity Imaging Techniques
Female
Fibrosis
Follow-Up Studies
Gastroenterology
Health aspects
Hepatitis
Hepatitis C
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - physiopathology
Hepatitis C, Chronic - virology
Hepatology
Histology
Humans
Interferon
Laboratories
Liver
Liver - drug effects
Liver - physiopathology
Liver - virology
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - drug therapy
Liver Cirrhosis - physiopathology
Liver diseases
Liver failure
Liver transplants
Longitudinal Studies
Male
Medicine
Middle Aged
Multivariate analysis
Patients
Stiffness
Therapy
Ultrasonic imaging
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Description
Summary:Liver stiffness (LS) measurement by means of transient elastography (TE) is accurate to predict fibrosis stage. The effect of antiviral treatment and virologic response on LS was assessed and compared with untreated patients with chronic hepatitis C (CHC). TE was performed at baseline, and at weeks 24, 48, and 72 in 515 patients with CHC. 323 treated (62.7%) and 192 untreated patients (37.3%) were assessed. LS experienced a significant decline in treated patients and remained stable in untreated patients at the end of study (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0047715