Hemoglobin A1c and arterial and ventricular stiffness in older adults

Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. We examined the association between HbA(1c), an AGE, with arterial and ventricular s...

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Published in:PloS one 2012-10, Vol.7 (10), p.e47941-e47941
Main Authors: Zieman, Susan J, Kamineni, Aruna, Ix, Joachim H, Barzilay, Joshua, Djoussé, Luc, Kizer, Jorge R, Biggs, Mary L, de Boer, Ian H, Chonchol, Michel, Gottdiener, John S, Selvin, Elizabeth, Newman, Anne B, Kuller, Lewis H, Siscovick, David S, Mukamal, Kenneth J
Format: Article
Language:English
Subjects:
Adult
Adults
Advanced glycosylation end products
African Continental Ancestry Group - genetics
Age
Aged
Aging
Ankle
Ankle Brachial Index
Arteries - diagnostic imaging
Arteries - physiopathology
Biology
Blood Glucose
Blood pressure
Blood Pressure - physiology
Body Mass Index
Correlation analysis
Cross-Sectional Studies
Diabetes mellitus
Drugs
Echocardiography
Fasting
Female
Genetic Association Studies
Glucose
Glycated Hemoglobin A - genetics
Glycated Hemoglobin A - metabolism
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - genetics
Glycosylated hemoglobin
Glycosylation
Health risk assessment
Heart
Heart Ventricles - physiopathology
Hemoglobin
Humans
Laboratory testing
Male
Measurement methods
Medicine
Middle Aged
Morbidity
Mortality
Older people
Population studies
Pressure measurement
Regression analysis
Regression models
Research design
Stiffening
Stiffness
Ultrasonography
Ultrasound
Vascular Stiffness
Ventricle
Womens health
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creator Zieman, Susan J
Kamineni, Aruna
Ix, Joachim H
Barzilay, Joshua
Djoussé, Luc
Kizer, Jorge R
Biggs, Mary L
de Boer, Ian H
Chonchol, Michel
Gottdiener, John S
Selvin, Elizabeth
Newman, Anne B
Kuller, Lewis H
Siscovick, David S
Mukamal, Kenneth J
description Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. We examined the association between HbA(1c), an AGE, with arterial and ventricular stiffness measures in older individuals without diabetes. Baseline HbA(1c) was measured in 830 participants free of diabetes defined by fasting glucose or medication use in the Cardiovascular Health Study, a population-based cohort study of adults aged ≥ 65 years. We performed cross-sectional analyses using baseline exam data including echocardiography, ankle and brachial blood pressure measurement, and carotid ultrasonography. We examined the adjusted associations between HbA(1c) and multiple arterial and ventricular stiffness measures by linear regression models and compared these results to the association of fasting glucose (FG) with like measures. HbA(1c) was correlated with fasting and 2-hour postload glucose levels (r = 0.21; p
doi_str_mv 10.1371/journal.pone.0047941
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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zieman, Susan J</au><au>Kamineni, Aruna</au><au>Ix, Joachim H</au><au>Barzilay, Joshua</au><au>Djoussé, Luc</au><au>Kizer, Jorge R</au><au>Biggs, Mary L</au><au>de Boer, Ian H</au><au>Chonchol, Michel</au><au>Gottdiener, John S</au><au>Selvin, Elizabeth</au><au>Newman, Anne B</au><au>Kuller, Lewis H</au><au>Siscovick, David S</au><au>Mukamal, Kenneth J</au><au>Hamel, Frederick G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoglobin A1c and arterial and ventricular stiffness in older adults</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-30</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e47941</spage><epage>e47941</epage><pages>e47941-e47941</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. We examined the association between HbA(1c), an AGE, with arterial and ventricular stiffness measures in older individuals without diabetes. Baseline HbA(1c) was measured in 830 participants free of diabetes defined by fasting glucose or medication use in the Cardiovascular Health Study, a population-based cohort study of adults aged ≥ 65 years. We performed cross-sectional analyses using baseline exam data including echocardiography, ankle and brachial blood pressure measurement, and carotid ultrasonography. We examined the adjusted associations between HbA(1c) and multiple arterial and ventricular stiffness measures by linear regression models and compared these results to the association of fasting glucose (FG) with like measures. HbA(1c) was correlated with fasting and 2-hour postload glucose levels (r = 0.21; p&lt;0.001 for both) and positively associated with greater body-mass index and black race. In adjusted models, HbA(1c) was not associated with any measure of arterial or ventricular stiffness, including pulse pressure (PP), carotid intima-media thickness, ankle-brachial index, end-arterial elastance, or left ventricular mass (LVM). FG levels were positively associated with systolic, diastolic and PP and LVM. In this sample of older adults without diabetes, HbA(1c) was not associated with arterial or ventricular stiffness measures, whereas FG levels were. The role of AGE in arterial and ventricular stiffness in older adults may be better assessed using alternate AGE markers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23118911</pmid><doi>10.1371/journal.pone.0047941</doi><tpages>e47941</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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issn 1932-6203
1932-6203
language eng
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source Publicly Available Content Database; PubMed Central
subjects Adult
Adults
Advanced glycosylation end products
African Continental Ancestry Group - genetics
Age
Aged
Aging
Ankle
Ankle Brachial Index
Arteries - diagnostic imaging
Arteries - physiopathology
Biology
Blood Glucose
Blood pressure
Blood Pressure - physiology
Body Mass Index
Correlation analysis
Cross-Sectional Studies
Diabetes mellitus
Drugs
Echocardiography
Fasting
Female
Genetic Association Studies
Glucose
Glycated Hemoglobin A - genetics
Glycated Hemoglobin A - metabolism
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - genetics
Glycosylated hemoglobin
Glycosylation
Health risk assessment
Heart
Heart Ventricles - physiopathology
Hemoglobin
Humans
Laboratory testing
Male
Measurement methods
Medicine
Middle Aged
Morbidity
Mortality
Older people
Population studies
Pressure measurement
Regression analysis
Regression models
Research design
Stiffening
Stiffness
Ultrasonography
Ultrasound
Vascular Stiffness
Ventricle
Womens health
title Hemoglobin A1c and arterial and ventricular stiffness in older adults
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