Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight

Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands...

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Bibliographic Details
Published in:PloS one 2012-11, Vol.7 (11), p.e48046
Main Authors: Molendijk, Marc L, Haffmans, Judith P M, Bus, Boudewijn A A, Spinhoven, Philip, Penninx, Brenda W J H, Prickaerts, Jos, Oude Voshaar, Richard C, Elzinga, Bernet M
Format: Article
Language:English
Subjects:
Adult
Anxiety
Anxiety - blood
Behavior
Biology
Body Mass Index
Brain
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Case-Control Studies
Cognition & reasoning
Correlation
Correlation coefficient
Correlation coefficients
Depression - blood
Female
Humans
Hypotheses
Male
Medicine
Mental depression
Middle Aged
Monthly variations
Netherlands
Primary care
Psychiatry
Regression Analysis
Rodents
Seasonal variations
Seasons
Social and Behavioral Sciences
Studies
Suicides & suicide attempts
Sunlight
Time Factors
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Summary:Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0048046