High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover

There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D w...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-11, Vol.7 (11), p.e47264-e47264
Main Authors: Lu, Han-Kui, Zhang, Zeng, Ke, Yao-Hua, He, Jin-Wei, Fu, Wen-Zhen, Zhang, Chang-Qing, Zhang, Zhen-Lin
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Aged, 80 and over
Albumin
Biology
Biomarkers - blood
Bone and Bones - metabolism
Bone density
Bone diseases
Bone surgery
Bone turnover
China - epidemiology
Cross-Sectional Studies
Female
Females
Genetic research
Hospitals
Humans
Lifestyles
Liver
Male
Males
Markers
Medicine
Mens health
Metabolism
Middle Aged
Normal distribution
Older people
Orthopedics
Osteoporosis
Parathyroid
Parathyroid hormone
Parathyroid Hormone - blood
Parathyroid hormones
Population
Prevalence
Type 2 diabetes
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - metabolism
Vitamin deficiency
Womens health
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3
cites cdi_FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3
container_end_page e47264
container_issue 11
container_start_page e47264
container_title PloS one
container_volume 7
creator Lu, Han-Kui
Zhang, Zeng
Ke, Yao-Hua
He, Jin-Wei
Fu, Wen-Zhen
Zhang, Chang-Qing
Zhang, Zhen-Lin
description There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20-89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (
doi_str_mv 10.1371/journal.pone.0047264
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1326725146</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477091539</galeid><doaj_id>oai_doaj_org_article_8474da838ed44546a7fea78596fd9090</doaj_id><sourcerecordid>A477091539</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3</originalsourceid><addsrcrecordid>eNqNk82O0zAQxyMEYpeFN0BgCQnBocWOnTjmgLQqH1tppZX4ulpOMmm8uHGxnUIfgPfGabOrBu0B5eB4_Jv_jGc8SfKU4DmhnLy5tr3rlJlvbAdzjBlPc3YvOSWCprM8xfT-0f9J8sj7a4wzWuT5w-QkpYSxguDT5M-FXrVo42CrDHQVINugrQ5qrTv0HunO902jKx2PdnGHFq3u1FvkwKigbedbvUG_dGhRaAEZ2ILxg8JGORXanbO6Rq1165giUl2N1sr9ALdHysEW4hXsFtzj5EGjjIcn43qWfPv44eviYnZ59Wm5OL-cVblIw6wQNasVz2lRsZKrDBdlWWa8EMAYqKxmOC95mpVNlnKWUuAAQuGqzERaFGVV0rPk-UF3Y6yXYwW9JDTNox9heSSWB6K26lpunI4p76RVWu4N1q2kckFXBmTBeMymoAXUjGUsV7wBxYtM5E0tsMBR690YrS_XUFfQBafMRHR60ulWruxWUiZoloso8GoUcPZnDz7ItfYVGKM6sH3Mm2REEBF7H9EX_6B3326kVrHbUneNjXGrQVSeM86xIBkdws7voOJXw1pXsW-NjvaJw-uJQ2QC_A4r1Xsvl18-_z979X3KvjxiW1AmtN6afv_0piA7gJWz3jtobotMsBym5aYacpgWOU5LdHt23KBbp5vxoH8BtPEQ4w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1326725146</pqid></control><display><type>article</type><title>High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Lu, Han-Kui ; Zhang, Zeng ; Ke, Yao-Hua ; He, Jin-Wei ; Fu, Wen-Zhen ; Zhang, Chang-Qing ; Zhang, Zhen-Lin</creator><contributor>Ning, Yi</contributor><creatorcontrib>Lu, Han-Kui ; Zhang, Zeng ; Ke, Yao-Hua ; He, Jin-Wei ; Fu, Wen-Zhen ; Zhang, Chang-Qing ; Zhang, Zhen-Lin ; Ning, Yi</creatorcontrib><description>There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20-89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (&lt;30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (&lt;20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as &lt;10, 10-20, 20-30, and ≥30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p&lt;0.001). There was an inverse relationship between the serum 25(OH)D and PTH concentrations in both genders, but no threshold of 25(OH)D at which PTH levels plateaued was observed. There were modest but significantly inverse relationships between the levels of 25(OH)D and bone turnover markers, but no plateau was observed for serum 25(OH)D levels up to 40 ng/mL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0047264</identifier><identifier>PMID: 23144810</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Aged, 80 and over ; Albumin ; Biology ; Biomarkers - blood ; Bone and Bones - metabolism ; Bone density ; Bone diseases ; Bone surgery ; Bone turnover ; China - epidemiology ; Cross-Sectional Studies ; Female ; Females ; Genetic research ; Hospitals ; Humans ; Lifestyles ; Liver ; Male ; Males ; Markers ; Medicine ; Mens health ; Metabolism ; Middle Aged ; Normal distribution ; Older people ; Orthopedics ; Osteoporosis ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - blood ; Parathyroid hormones ; Population ; Prevalence ; Type 2 diabetes ; Vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - metabolism ; Vitamin deficiency ; Womens health ; Young Adult</subject><ispartof>PloS one, 2012-11, Vol.7 (11), p.e47264-e47264</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Lu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Lu et al 2012 Lu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3</citedby><cites>FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1326725146/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1326725146?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23144810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ning, Yi</contributor><creatorcontrib>Lu, Han-Kui</creatorcontrib><creatorcontrib>Zhang, Zeng</creatorcontrib><creatorcontrib>Ke, Yao-Hua</creatorcontrib><creatorcontrib>He, Jin-Wei</creatorcontrib><creatorcontrib>Fu, Wen-Zhen</creatorcontrib><creatorcontrib>Zhang, Chang-Qing</creatorcontrib><creatorcontrib>Zhang, Zhen-Lin</creatorcontrib><title>High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20-89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (&lt;30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (&lt;20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as &lt;10, 10-20, 20-30, and ≥30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p&lt;0.001). There was an inverse relationship between the serum 25(OH)D and PTH concentrations in both genders, but no threshold of 25(OH)D at which PTH levels plateaued was observed. There were modest but significantly inverse relationships between the levels of 25(OH)D and bone turnover markers, but no plateau was observed for serum 25(OH)D levels up to 40 ng/mL.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Biology</subject><subject>Biomarkers - blood</subject><subject>Bone and Bones - metabolism</subject><subject>Bone density</subject><subject>Bone diseases</subject><subject>Bone surgery</subject><subject>Bone turnover</subject><subject>China - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Females</subject><subject>Genetic research</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lifestyles</subject><subject>Liver</subject><subject>Male</subject><subject>Males</subject><subject>Markers</subject><subject>Medicine</subject><subject>Mens health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Normal distribution</subject><subject>Older people</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroid hormones</subject><subject>Population</subject><subject>Prevalence</subject><subject>Type 2 diabetes</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - metabolism</subject><subject>Vitamin deficiency</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk82O0zAQxyMEYpeFN0BgCQnBocWOnTjmgLQqH1tppZX4ulpOMmm8uHGxnUIfgPfGabOrBu0B5eB4_Jv_jGc8SfKU4DmhnLy5tr3rlJlvbAdzjBlPc3YvOSWCprM8xfT-0f9J8sj7a4wzWuT5w-QkpYSxguDT5M-FXrVo42CrDHQVINugrQ5qrTv0HunO902jKx2PdnGHFq3u1FvkwKigbedbvUG_dGhRaAEZ2ILxg8JGORXanbO6Rq1165giUl2N1sr9ALdHysEW4hXsFtzj5EGjjIcn43qWfPv44eviYnZ59Wm5OL-cVblIw6wQNasVz2lRsZKrDBdlWWa8EMAYqKxmOC95mpVNlnKWUuAAQuGqzERaFGVV0rPk-UF3Y6yXYwW9JDTNox9heSSWB6K26lpunI4p76RVWu4N1q2kckFXBmTBeMymoAXUjGUsV7wBxYtM5E0tsMBR690YrS_XUFfQBafMRHR60ulWruxWUiZoloso8GoUcPZnDz7ItfYVGKM6sH3Mm2REEBF7H9EX_6B3326kVrHbUneNjXGrQVSeM86xIBkdws7voOJXw1pXsW-NjvaJw-uJQ2QC_A4r1Xsvl18-_z979X3KvjxiW1AmtN6afv_0piA7gJWz3jtobotMsBym5aYacpgWOU5LdHt23KBbp5vxoH8BtPEQ4w</recordid><startdate>20121108</startdate><enddate>20121108</enddate><creator>Lu, Han-Kui</creator><creator>Zhang, Zeng</creator><creator>Ke, Yao-Hua</creator><creator>He, Jin-Wei</creator><creator>Fu, Wen-Zhen</creator><creator>Zhang, Chang-Qing</creator><creator>Zhang, Zhen-Lin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121108</creationdate><title>High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover</title><author>Lu, Han-Kui ; Zhang, Zeng ; Ke, Yao-Hua ; He, Jin-Wei ; Fu, Wen-Zhen ; Zhang, Chang-Qing ; Zhang, Zhen-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Biology</topic><topic>Biomarkers - blood</topic><topic>Bone and Bones - metabolism</topic><topic>Bone density</topic><topic>Bone diseases</topic><topic>Bone surgery</topic><topic>Bone turnover</topic><topic>China - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Females</topic><topic>Genetic research</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lifestyles</topic><topic>Liver</topic><topic>Male</topic><topic>Males</topic><topic>Markers</topic><topic>Medicine</topic><topic>Mens health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Normal distribution</topic><topic>Older people</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroid hormones</topic><topic>Population</topic><topic>Prevalence</topic><topic>Type 2 diabetes</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - metabolism</topic><topic>Vitamin deficiency</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Han-Kui</creatorcontrib><creatorcontrib>Zhang, Zeng</creatorcontrib><creatorcontrib>Ke, Yao-Hua</creatorcontrib><creatorcontrib>He, Jin-Wei</creatorcontrib><creatorcontrib>Fu, Wen-Zhen</creatorcontrib><creatorcontrib>Zhang, Chang-Qing</creatorcontrib><creatorcontrib>Zhang, Zhen-Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Han-Kui</au><au>Zhang, Zeng</au><au>Ke, Yao-Hua</au><au>He, Jin-Wei</au><au>Fu, Wen-Zhen</au><au>Zhang, Chang-Qing</au><au>Zhang, Zhen-Lin</au><au>Ning, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-11-08</date><risdate>2012</risdate><volume>7</volume><issue>11</issue><spage>e47264</spage><epage>e47264</epage><pages>e47264-e47264</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20-89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (&lt;30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (&lt;20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as &lt;10, 10-20, 20-30, and ≥30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p&lt;0.001). There was an inverse relationship between the serum 25(OH)D and PTH concentrations in both genders, but no threshold of 25(OH)D at which PTH levels plateaued was observed. There were modest but significantly inverse relationships between the levels of 25(OH)D and bone turnover markers, but no plateau was observed for serum 25(OH)D levels up to 40 ng/mL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23144810</pmid><doi>10.1371/journal.pone.0047264</doi><tpages>e47264</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2012-11, Vol.7 (11), p.e47264-e47264
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1326725146
source Open Access: PubMed Central; Publicly Available Content Database
subjects Adult
Adults
Aged
Aged, 80 and over
Albumin
Biology
Biomarkers - blood
Bone and Bones - metabolism
Bone density
Bone diseases
Bone surgery
Bone turnover
China - epidemiology
Cross-Sectional Studies
Female
Females
Genetic research
Hospitals
Humans
Lifestyles
Liver
Male
Males
Markers
Medicine
Mens health
Metabolism
Middle Aged
Normal distribution
Older people
Orthopedics
Osteoporosis
Parathyroid
Parathyroid hormone
Parathyroid Hormone - blood
Parathyroid hormones
Population
Prevalence
Type 2 diabetes
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - metabolism
Vitamin deficiency
Womens health
Young Adult
title High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A45%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20prevalence%20of%20vitamin%20D%20insufficiency%20in%20China:%20relationship%20with%20the%20levels%20of%20parathyroid%20hormone%20and%20markers%20of%20bone%20turnover&rft.jtitle=PloS%20one&rft.au=Lu,%20Han-Kui&rft.date=2012-11-08&rft.volume=7&rft.issue=11&rft.spage=e47264&rft.epage=e47264&rft.pages=e47264-e47264&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0047264&rft_dat=%3Cgale_plos_%3EA477091539%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-89d4da7638c4b7a508bbb5789e44ea5d406b725bf527423e7ee9a0cb59288bcb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1326725146&rft_id=info:pmid/23144810&rft_galeid=A477091539&rfr_iscdi=true