Gamma-glutamyltransferase level and risk of hypertension: a systematic review and meta-analysis

Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematic review and meta-analysis to evaluate the exact association betwee...

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Published in:PloS one 2012-11, Vol.7 (11), p.e48878-e48878
Main Authors: Liu, Cun-Fei, Gu, Yu-Ting, Wang, Hai-Ya, Fang, Ning-Yuan
Format: Article
Language:English
Subjects:
Alcohol
Alcohol use
Biomarkers - blood
Citation analysis
Citation indexes
Diabetes
Epidemiology
g-Glutamyltransferase
gamma-Glutamyltransferase - blood
Humans
Hypertension
Hypertension - blood
Male
Medical ethics
Medicine
Meta-analysis
Metabolic syndrome
Middle age
Odds Ratio
Prospective Studies
Risk
Risk Factors
Sensitivity analysis
Studies
Systematic review
γ-Glutamyltransferase
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description Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematic review and meta-analysis to evaluate the exact association between GGT level and subsequent development of hypertension. We searched Pubmed, Embase, and Science Citation Index (ISI Web of Science) for prospective cohort studies examining the association between GGT level and hypertension. Then, pooled effect estimates (RRs) for the association between GGT level and hypertension were calculated. A total of 13 prospective cohort studies including 43314 participants and 5280 cases of hypertension were included. The pooled RR of hypertension was 1.94(95%CI: 1.55-2.43; P
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Subgroup analyses showed significant positive associations in each subgroup except in ≧160/95 subgroup (RR: 2.56, 95%CI: 0.87-7.54; P = 0.088) and nondrinkers subgroup (RR: 1.76, 95%CI: 0.88-3.53; P = 0.113). Sensitivity analyses showed no single study significantly affects the pooled RRs. No publication bias was found in our meta-analysis. GGT level is positively associated with the development of hypertension. 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subjects Alcohol
Alcohol use
Biomarkers - blood
Citation analysis
Citation indexes
Diabetes
Epidemiology
g-Glutamyltransferase
gamma-Glutamyltransferase - blood
Humans
Hypertension
Hypertension - blood
Male
Medical ethics
Medicine
Meta-analysis
Metabolic syndrome
Middle age
Odds Ratio
Prospective Studies
Risk
Risk Factors
Sensitivity analysis
Studies
Systematic review
γ-Glutamyltransferase
title Gamma-glutamyltransferase level and risk of hypertension: a systematic review and meta-analysis
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