Molecular dissection of the basal clades in the human Y chromosome phylogenetic tree

One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the r...

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Bibliographic Details
Published in:PloS one 2012-11, Vol.7 (11), p.e49170
Main Authors: Scozzari, Rosaria, Massaia, Andrea, D'Atanasio, Eugenia, Myres, Natalie M, Perego, Ugo A, Trombetta, Beniamino, Cruciani, Fulvio
Format: Article
Language:English
Subjects:
Analysis
Biology
Chromosomes
Chromosomes, Human, Y - genetics
Darwin, Charles (1809-1882)
Dissection
Genome, Human
Genomes
Genomics
Haplotypes - genetics
Humans
Microsatellite Repeats - genetics
Mutation
Phylogenetics
Phylogeny
Polymorphism, Single Nucleotide
Social and Behavioral Sciences
Surgery
Y chromosomes
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Summary:One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the revised phylogeny. This analysis made it possible to identify new haplogroups and to resolve a deep trifurcation within haplogroup B2. Our data provide a highly resolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrant of the African continent for the human MSY diversity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0049170