Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model

Zinc (Zn) deficiency often occurs in the patients with diabetes. Effects of Zn deficiency on diabetes-induced hepatic injury were investigated. Type 1 diabetes was induced in FVB mice with multiple low-dose streptozotocin. Hyperglycemic and age-matched control mice were treated with and without Zn c...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e49257-e49257
Main Authors: Zhang, Chi, Lu, Xuemian, Tan, Yi, Li, Bing, Miao, Xiao, Jin, Litai, Shi, Xue, Zhang, Xiang, Miao, Lining, Li, Xiaokun, Cai, Lu
Format: Article
Language:English
Subjects:
Accumulation
Activation
AKT protein
Alanine
Alanine transaminase
Animals
Apoptosis
Biology
Body weight
Cardiovascular disease
Cell death
Cell Line, Tumor
Cytokinins
Cytoplasm
Damage accumulation
Diabetes mellitus
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetes therapy
Diet therapy
Disease Models, Animal
Down-Regulation
Endoplasmic reticulum
Ethylenediamine
Ethylenediamines
Fyn protein
Glucose
Glycogen Synthase Kinase 3 - metabolism
Glycogen Synthase Kinase 3 beta
Humans
Hyperglycemia - metabolism
Hyperglycemia - pathology
Inflammation
Inflammation - metabolism
Inflammation - pathology
Injuries
Insulin
Insulin resistance
Insulin Resistance - physiology
Liver
Liver - metabolism
Liver - pathology
Liver diseases
Male
Medicine
Mice
Mortality
Nuclear transport
Nutrient deficiency
Oxidation resistance
Oxidative stress
Oxidative Stress - physiology
Phosphorylation
Proto-Oncogene Proteins c-akt - metabolism
Regulators
Rodents
Streptozocin
Supplements
Transcription
Translocation
Type 2 diabetes
Zinc
Zinc (Nutrient)
Zinc - deficiency
Zinc compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zinc (Zn) deficiency often occurs in the patients with diabetes. Effects of Zn deficiency on diabetes-induced hepatic injury were investigated. Type 1 diabetes was induced in FVB mice with multiple low-dose streptozotocin. Hyperglycemic and age-matched control mice were treated with and without Zn chelator, N,N,N',N'-tetrakis (2-pyridylemethyl) ethylenediamine (TPEN), at 5 mg/kg body-weight daily for 4 months. Hepatic injury was examined by serum alanine aminotransferase (ALT) level and liver histopathological and biochemical changes. Hepatic Zn deficiency (lower than control level, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0049257