Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster

Immunity and metabolism are intimately linked; manipulating metabolism, either through diet or genetics, has the power to alter survival during infection. However, despite metabolism's powerful ability to alter the course of infections, little is known about what being "sick" means me...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e50679-e50679
Main Authors: Chambers, Moria C, Song, Kyung Han, Schneider, David S
Format: Article
Language:English
Subjects:
Acids
Amino acids
Amino Acids - chemistry
Amino Acids - metabolism
Analysis
Animals
Anorexia
Bacterial infections
Biology
Biomarkers
Biosynthesis
Diet
Drosophila
Drosophila melanogaster
Energy metabolism
Energy storage
Fatty acids
Fatty Acids - metabolism
Gene Expression Regulation
Genetics
Glucose metabolism
Glycogen
Glycogen - chemistry
Glycogen - metabolism
Glycolysis
Health aspects
Immunity
Immunity, Innate
Immunology
Infections
Insects
Kinases
Listeria
Listeria monocytogenes
Listeria monocytogenes - metabolism
Listeriosis - immunology
Listeriosis - metabolism
Medicine
Melanins - metabolism
Melanization
Metabolism
Metabolites
Metabolomics
Models, Biological
Mutation
Nucleotides - genetics
Oxidases
Oxidation
Oxidizing agents
Oxygen - metabolism
Pathogenesis
Physiological aspects
Proteins
Pseudomonas
Pseudomonas entomophila
Stem Cells
Time Factors
Triglycerides
Triglycerides - metabolism
Tyrosine
Uric acid
Uric Acid - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Immunity and metabolism are intimately linked; manipulating metabolism, either through diet or genetics, has the power to alter survival during infection. However, despite metabolism's powerful ability to alter the course of infections, little is known about what being "sick" means metabolically. Here we describe the metabolic changes occurring in a model system when Listeria monocytogenes causes a lethal infection in Drosophila melanogaster. L. monocytogenes infection alters energy metabolism; the flies gradually lose both of their energy stores, triglycerides and glycogen, and show decreases in both intermediate metabolites and enzyme message for the two main energy pathways, beta-oxidation and glycolysis. L. monocytogenes infection also causes enzymatic reduction in the anti-oxidant uric acid, and knocking out the enzyme uric oxidase has a complicated effect on immunity. Free amino acid levels also change during infection, including a drop in tyrosine levels which may be due to robust L. monocytogenes induced melanization.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0050679