Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients

YKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS....

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e51722-e51722
Main Authors: Park, Hyun Young, Jun, Chang-Duk, Jeon, Se-Jeong, Choi, See-Sung, Kim, Hak-Ryul, Choi, Dan-Bee, Kwak, Seongae, Lee, Hak-Seung, Cheong, Jin Sung, So, Hong-Seob, Lee, Young-Jin, Park, Do-Sim
Format: Article
Language:English
Subjects:
Adipokines - blood
Aged
Atherosclerosis
Biomarkers
Brain Infarction - blood
Brain Infarction - diagnosis
C-reactive protein
C-Reactive Protein - metabolism
Case-Control Studies
Chitinase
Chitinase-3-Like Protein 1
Cholesterol
Clinical medicine
Comparative analysis
Consent
Correlation
Cross infection
Cytokines
Diabetes
Female
Hospitals
Humans
Inflammation
Ischemia
Laboratories
Lectins - blood
Male
Medical screening
Medicine
Meningitis
Metabolism
Middle Aged
Nervous system diseases
Neurological diseases
NMR
Nosocomial infections
Nuclear magnetic resonance
Patient outcomes
Patients
Prognosis
Proteins
Reproducibility of Results
Severity of Illness Index
Stroke
Stroke - blood
Stroke - diagnosis
Stroke patients
Time Factors
Tumor necrosis factor-TNF
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Summary:YKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS. Serum YKL-40 and C-reactive protein (CRP) levels were monitored over time in AIS patients (n = 105) and compared with those of stroke-free controls (n = 34). Infarct volume and stroke severity (National Institutes of Health Stroke Scale; NIHSS) were measured within 48 hours of symptom onset, and functional outcome (modified Rankin Scale; mRS) was measured 3 months after AIS. Within 12 hours of symptom onset, levels of YKL-40 (251 vs. 41 ng/mL) and CRP (1.50 vs. 0.96 µg/mL) were elevated in AIS patients compared to controls. The power of YKL-40 for discriminating AIS patients from controls was superior to that of CRP (area under the curve 0.84 vs. 0.64) and YKL-40 (r = 0.26, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0051722