Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption

Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. To investigate whether MC4R and FTO associations...

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Published in:PloS one 2012-12, Vol.7 (12), p.e52344-e52344
Main Authors: Corella, Dolores, Ortega-Azorín, Carolina, Sorlí, Jose V, Covas, M. Isabel, Carrasco, Paula, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, Arós, Fernando, Lapetra, José, Serra-Majem, Lluís, Lamuela-Raventos, Rosa, Gómez-Gracia, Enrique, Fiol, Miquel, Pintó, Xavier, Ros, Emilio, Martí, Amelia, Coltell, Oscar, Ordovás, Jose M, Estruch, Ramon, Dasgupta, Kaberi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alcohol
alcohol drinking
Alcohol Drinking - genetics
Alcohol use
Alcohols
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Biological effects
Body fat
Body mass
Body Mass Index
Body size
Body weight
Cardiovascular diseases
Consum d'alcohol
Diabetes
Diet
Drinking (Alcoholic beverages)
Drinking of alcoholic beverages
energy
Epidemiology
Estils de vida
Ethanol
Exercici
Exercise
Female
Food intake
Food science
Genes
Genetic aspects
Health care
Health risks
Hospitals
Humans
Internal medicine
Life Style
lifestyle
Lifestyles
Male
Medicine
Mediterranean diet
Melanocortin
Melanocortin MC4 receptors
Middle Aged
Mutation
Nutrition research
Obesitat
Obesity
Obesity - genetics
Physical activity
Physical fitness
Preventive medicine
Proteins - genetics
Public health
questionnaires
Receptor, Melanocortin, Type 4 - genetics
Risk
risk groups
Social and Behavioral Sciences
Statistics
Type 2 diabetes
waist circumference
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Summary:Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0052344