Selection and characterization of a candidate therapeutic bacteriophage that lyses the Escherichia coli O104:H4 strain from the 2011 outbreak in Germany

In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak st...

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e52709
Main Authors: Merabishvili, Maia, De Vos, Daniel, Verbeken, Gilbert, Kropinski, Andrew M, Vandenheuvel, Dieter, Lavigne, Rob, Wattiau, Pierre, Mast, Jan, Ragimbeau, Catherine, Mossong, Joel, Scheres, Jacques, Chanishvili, Nina, Vaneechoutte, Mario, Pirnay, Jean-Paul
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
Bacteriology
Bacteriolysis
Bacteriophages - genetics
Bacteriophages - isolation & purification
Bacteriophages - ultrastructure
Biology
Cholera
Clinical trials
Diarrhea
Disease Outbreaks
E coli
Epidemics
Epidemiology
Escherichia coli
Escherichia coli Infections - epidemiology
Genes
Genomes
Germany - epidemiology
Health aspects
Health surveillance
Hemolytic uremic syndrome
Hemolytic-Uremic Syndrome - epidemiology
Hospitals
Humans
Infections
Infectious diseases
Laboratories
Medicine
Microbiology
Molecular biology
Open Reading Frames
Outbreaks
Phages
Public health
Regulatory approval
Shiga-Toxigenic Escherichia coli - classification
Shiga-Toxigenic Escherichia coli - virology
Toxins
Virology
Zoonoses
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Summary:In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0052709