Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans

Recent studies in population of European ancestry have shown that 30% ~ 50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromos...

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Bibliographic Details
Published in:PLoS genetics 2013-03, Vol.9 (3), p.e1003355-e1003355
Main Authors: Yang, Jian, Lee, Taeheon, Kim, Jaemin, Cho, Myeong-Chan, Han, Bok-Ghee, Lee, Jong-Young, Lee, Hyun-Jeong, Cho, Seoae, Kim, Heebal
Format: Article
Language:English
Subjects:
Analysis
Asian Continental Ancestry Group - genetics
Biology
Body Height - genetics
Body Mass Index
Chromosomes
Estimates
Expected values
Genetic Variation
Genetics
Genome, Human
Genome-Wide Association Study
Genomes
Genotype
Human genetics
Humans
Identification and classification
Korea
Models, Genetic
Multifactorial Inheritance - genetics
Phenotype
Polymorphism, Single Nucleotide
Quantitative trait loci
Rheumatoid arthritis
Rural development
Schizophrenia
Single nucleotide polymorphisms
Testing
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Summary:Recent studies in population of European ancestry have shown that 30% ~ 50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosomes are in proportion to their length. Using genome-wide estimation and partitioning approaches, we analysed 49 human quantitative traits, many of which are relevant to human diseases, in 7,170 unrelated Korean individuals genotyped on 326,262 SNPs. For 43 of the 49 traits, we estimated a nominally significant (P
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1003355