Clinical value of NGAL, L-FABP and albuminuria in predicting GFR decline in type 2 diabetes mellitus patients

Neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid binding protein (L-FABP) are emerging as excellent biomarkers in the urine and plasma for the early prediction of acute and chronic kidney injury. The aims of this prospective study were to determine the role of albuminuria,...

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Bibliographic Details
Published in:PloS one 2013-01, Vol.8 (1), p.e54863-e54863
Main Authors: Chou, Kuei-Mei, Lee, Chin-Chan, Chen, Chih-Huang, Sun, Chiao-Yin
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - complications
Acute Kidney Injury - physiopathology
Acute Kidney Injury - urine
Acute-Phase Proteins - urine
Aged
Albumin
Albuminuria - blood
Albuminuria - urine
Biology
Biomarkers
Biomarkers - blood
Biomarkers - urine
Cardiovascular disease
Correlation
Correlation analysis
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - urine
Diabetic Nephropathies - blood
Diabetic Nephropathies - physiopathology
Diabetic Nephropathies - urine
Diabetics
Endocrinology
Epidermal growth factor receptors
Excretion
Fatty acid-binding protein
Fatty Acid-Binding Proteins - blood
Fatty Acid-Binding Proteins - urine
Fatty acids
Female
Gelatinase
Glomerular Filtration Rate
Hospitals
Humans
Injury analysis
Internal medicine
Kidney diseases
Kidneys
Laboratories
Lipocalin
Lipocalin-2
Lipocalins - blood
Lipocalins - urine
Liver
Male
Medical research
Medicine
Metabolism
Middle Aged
Nephrology
Neutrophils
Pathogenesis
Patients
Predictions
Predictive Value of Tests
Protein binding
Proto-Oncogene Proteins - blood
Proto-Oncogene Proteins - urine
Regression analysis
Type 2 diabetes
Urine
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Summary:Neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid binding protein (L-FABP) are emerging as excellent biomarkers in the urine and plasma for the early prediction of acute and chronic kidney injury. The aims of this prospective study were to determine the role of albuminuria, and that of serum and urine levels of NGAL and L-FABP as predictors of a decline in the glomerular filtration rate (GFR) in patients with type 2 diabetes. A longitudinal cohort study with one hundred forty type 2 diabetic patients was conducted. Serum and urine levels of NGAL and L-FABP, and the urine albumin excretion rate were determined. The correlation between the kidney injury biomarkers and rate of GFR decline was analyzed. The eGFR of study subjects decreased significantly as the study progressed (86.4±31.1 vs. 74.4±27.3 ml/min/1.73 m(2), P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0054863