Detection of bocavirus in children suffering from acute respiratory tract infections in Saudi Arabia

Human bocavirus (HBoV) was recently discovered in children with respiratory distress and/or diarrhea. To our knowledge, no previous study has reported the existence of bocavirus in Saudi Arabia. Swabs samples from 80 children with respiratory tract infections were examined for the presence of HBoV....

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Bibliographic Details
Published in:PloS one 2013-01, Vol.8 (1), p.e55500-e55500
Main Authors: Abdel-Moneim, Ahmed S, Kamel, Mahmoud M, Al-Ghamdi, Abdullhamid S, Al-Malky, Mater I R
Format: Article
Language:English
Subjects:
Biology
Child
Child, Preschool
Children
Diarrhea
Female
Gene sequencing
Genetic aspects
Health aspects
Human bocavirus - classification
Human bocavirus - genetics
Humans
Infant
Infant, Newborn
Infection
Infections
Male
Medicine
Molecular Sequence Data
Parvoviridae Infections - epidemiology
Pathogens
Patients
Pediatrics
Phylogenetics
Phylogeny
Polymerase chain reaction
Prevalence
Respiratory tract
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - epidemiology
Saudi Arabia - epidemiology
Viral Proteins - genetics
Viruses
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Summary:Human bocavirus (HBoV) was recently discovered in children with respiratory distress and/or diarrhea. To our knowledge, no previous study has reported the existence of bocavirus in Saudi Arabia. Swabs samples from 80 children with respiratory tract infections were examined for the presence of HBoV. Real-time polymerase chain reaction was used as a sensitive method to detect the HBoV. Direct gene sequencing was used to determine the genotype of the detected virus isolates. HBoV was detected in 22.5% of the examined patients. The NP1 partial gene sequence from all patients showed that the circulated strains were related to HBoV-1 genotype. Most of HBoV infected patients showed evidence of mixed coinfection with other viral pathogens. The current study clearly demonstrated that genetically conserved HBoV1 circulates in Saudi Arabia. Interestingly, most of the HBoV1 infected cases were associated with high rates of co-infections with other viruses.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0055500