Differentiating non-motor symptoms in Parkinson's disease from controls and hemifacial spasm

Non-motor symptoms (NMS) are important manifestations of Parkinson's disease (PD) that reduce patients' health-related quality of life. Some NMS may also be caused by age-related changes, or manifested as a psychological reaction to a chronic neurological condition. This case-control study...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e49596-e49596
Main Authors: Yong, Ming-Hui, Allen, Jr, John C, Prakash, Kumar M, Tan, Eng-King
Format: Article
Language:English
Subjects:
Age
Aged
Attention
Biology
Case-Control Studies
Chronic illnesses
Cognitive ability
Comparative analysis
Constipation
Diabetes
Disease control
Fatigue
Female
Generalized linear models
Hemifacial Spasm - physiopathology
Humans
Legs
Male
Medical research
Medical schools
Medicine
Middle Aged
Movement disorders
Nervous system
Neurodegenerative diseases
Neurology
Neurosciences
Olfaction
Parkinson Disease - physiopathology
Parkinson's disease
Pathology
Patients
Quality of life
Saliva
Singapore
Sleep
Smell
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Summary:Non-motor symptoms (NMS) are important manifestations of Parkinson's disease (PD) that reduce patients' health-related quality of life. Some NMS may also be caused by age-related changes, or manifested as a psychological reaction to a chronic neurological condition. This case-control study compared the NMS burden among PD patients, healthy controls and hemifacial spasm (HFS) patients. In addition, we determined the NMS that discriminated between PD and non-PD subjects. 425 subjects were recruited from a tertiary hospital in Singapore (200 PD patients, 150 healthy controls and 75 HFS patients). NMS burden in subjects was measured using the Non-Motor Symptoms Scale (NMSS). NMSS total score was significantly higher in PD patients (37.9±2.6) compared to healthy controls (11.2±0.9) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0049596