Tracking dynamic microvascular changes during healing after complete biopsy punch on the mouse pinna using optical microangiography

Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and chronic m...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e57976-e57976
Main Authors: Jung, Yeongri, Dziennis, Suzan, Zhi, Zhongwei, Reif, Roberto, Zheng, Ying, Wang, Ruikang K
Format: Article
Language:English
Subjects:
Angiogenesis
Angiography
Angiography - methods
Animals
Bioengineering
Biology
Biopsy
Biopsy - adverse effects
Blood
Blood flow
Capillaries
Diabetes
Ear Auricle - surgery
Feasibility Studies
Flow velocity
Imaging, Three-Dimensional
Medical imaging
Medicine
Mice
Microscopy
Microtechnology - methods
Microvasculature
Microvessels - diagnostic imaging
Microvessels - pathology
Microvessels - physiopathology
Mouse devices
Optics
Physics
Studies
Time Factors
Tissues
Tomography
Tortuosity
Tracking
Ulcers
Wound Healing
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Summary:Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and chronic microvascular and tissue responses upon an injury in vivo. A tissue wound was induced using a 0.5 mm biopsy punch on a mouse pinna. The changes in the microangiography, blood flow velocity and direction were quantified for the acute (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057976