Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction

Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of thi...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e57648-e57648
Main Authors: Erer, Hatice Betül, Güvenç, Tolga Sinan, Kemik, Ahu Sarbay, Yılmaz, Hale Yaka, Kul, Şeref, Altay, Servet, Sayar, Nurten, Kaya, Yüksel, Eren, Mehmet
Format: Article
Language:English
Subjects:
Adult
Antibodies
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Blood & organ donations
Calcium-binding protein
Cardiology
Cardiomyopathy
Cardiovascular disease
Congenital diseases
Dilated cardiomyopathy
Echocardiography
Electrocardiography
Female
Heart
Heart attacks
Heart Defects, Congenital - blood
Heart Defects, Congenital - physiopathology
Heart diseases
Heart failure
Hospitals
Humans
Immunoassay
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Male
Medicine
Myocardium
Patients
Rodents
Stroke Volume
Surgery
Thoracic surgery
Troponin
Troponin I
Troponin I - blood
Troponin I - immunology
Troponin T
Troponin T - blood
Troponin T - immunology
Ventricle
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Summary:Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of this complication is not known. Anti-troponin antibodies are formed against circulating cardiac troponins after an acute coronary event or conditions associated with chronic myocyte necrosis, such as dilated cardiomyopathy. In present study, we aimed to investigate cardiac troponins and anti troponin autoantibodies in ventricular noncompaction/hypertrabeculation patients with/without reduced ejection fraction. A total of 50 patients with ventricular noncompaction and 23 healthy volunteers were included in this study. Noncompaction/hypertrabeculation was diagnosed with two-dimensional echocardiography using appropriate criteria. Depending on ejection fraction, patients were grouped into noncompaction with preserved EF (LVEF >50%, n = 24) and noncompaction with reduced EF (LVEF
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057648