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Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers
The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl. 10 healthy volunteers and 21 patients enrolled in the study (19 males a...
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| Published in: | PloS one 2013-02, Vol.8 (2), p.e57671-e57671 |
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| creator | Shiga, Hideaki Taki, Junichi Washiyama, Kohshin Yamamoto, Junpei Kinase, Sakae Okuda, Koichi Kinuya, Seigo Watanabe, Naoto Tonami, Hisao Koshida, Kichiro Amano, Ryohei Furukawa, Mitsuru Miwa, Takaki |
| description | The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.
10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.
Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.
Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction. |
| doi_str_mv | 10.1371/journal.pone.0057671 |
| format | article |
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10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.
Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.
Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0057671</identifier><identifier>PMID: 23469046</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Administration, Intranasal ; Adult ; Aged ; Biological Transport ; Biology ; Case-Control Studies ; Chronic infection ; Computed tomography ; Correlation ; Craniocerebral Trauma - complications ; Female ; Females ; Head injuries ; Hospitals ; Humans ; Infections ; Intranasal administration ; Magnetic Resonance Imaging ; Male ; Males ; Medical imaging ; Medical technology ; Medicine ; Middle Aged ; Migration ; NMR ; Nuclear magnetic resonance ; Object recognition ; Odor recognition ; Odor thresholds ; Odors ; Olfaction ; Olfaction Disorders - diagnostic imaging ; Olfaction Disorders - etiology ; Olfaction Disorders - metabolism ; Olfaction Disorders - physiopathology ; Olfactometers ; Olfactory bulb ; Olfactory Bulb - diagnostic imaging ; Olfactory Bulb - metabolism ; Olfactory Bulb - pathology ; Olfactory Bulb - physiopathology ; Olfactory nerve ; Olfactory Nerve - diagnostic imaging ; Olfactory Nerve - metabolism ; Olfactory Nerve - pathology ; Olfactory Nerve - physiopathology ; Otolaryngology ; Patients ; Respiratory tract ; Respiratory tract diseases ; Respiratory Tract Infections - complications ; Rhinosinusitis ; Science ; Sensory Thresholds ; Single photon emission computed tomography ; Sinusitis - complications ; Smell ; Thallium ; Thallium isotopes ; Thallium Radioisotopes - administration & dosage ; Thallium Radioisotopes - metabolism ; Thallium-201 ; Thresholds ; Tomography ; Tomography, Emission-Computed, Single-Photon ; Trauma</subject><ispartof>PloS one, 2013-02, Vol.8 (2), p.e57671-e57671</ispartof><rights>2013 Shiga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Shiga et al 2013 Shiga et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-d4fbc60327699c5185b48dd12d7556a5ec90214ffd7dab439a3a51d7094282283</citedby><cites>FETCH-LOGICAL-c570t-d4fbc60327699c5185b48dd12d7556a5ec90214ffd7dab439a3a51d7094282283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1330882896/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1330882896?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23469046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hummel, Thomas</contributor><creatorcontrib>Shiga, Hideaki</creatorcontrib><creatorcontrib>Taki, Junichi</creatorcontrib><creatorcontrib>Washiyama, Kohshin</creatorcontrib><creatorcontrib>Yamamoto, Junpei</creatorcontrib><creatorcontrib>Kinase, Sakae</creatorcontrib><creatorcontrib>Okuda, Koichi</creatorcontrib><creatorcontrib>Kinuya, Seigo</creatorcontrib><creatorcontrib>Watanabe, Naoto</creatorcontrib><creatorcontrib>Tonami, Hisao</creatorcontrib><creatorcontrib>Koshida, Kichiro</creatorcontrib><creatorcontrib>Amano, Ryohei</creatorcontrib><creatorcontrib>Furukawa, Mitsuru</creatorcontrib><creatorcontrib>Miwa, Takaki</creatorcontrib><title>Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.
10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.
Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.
Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.</description><subject>Administration, Intranasal</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological Transport</subject><subject>Biology</subject><subject>Case-Control Studies</subject><subject>Chronic infection</subject><subject>Computed tomography</subject><subject>Correlation</subject><subject>Craniocerebral Trauma - complications</subject><subject>Female</subject><subject>Females</subject><subject>Head injuries</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Intranasal administration</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medical technology</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Migration</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Object recognition</subject><subject>Odor recognition</subject><subject>Odor thresholds</subject><subject>Odors</subject><subject>Olfaction</subject><subject>Olfaction Disorders - diagnostic imaging</subject><subject>Olfaction Disorders - etiology</subject><subject>Olfaction Disorders - metabolism</subject><subject>Olfaction Disorders - physiopathology</subject><subject>Olfactometers</subject><subject>Olfactory bulb</subject><subject>Olfactory Bulb - diagnostic imaging</subject><subject>Olfactory Bulb - metabolism</subject><subject>Olfactory Bulb - pathology</subject><subject>Olfactory Bulb - physiopathology</subject><subject>Olfactory nerve</subject><subject>Olfactory Nerve - diagnostic imaging</subject><subject>Olfactory Nerve - metabolism</subject><subject>Olfactory Nerve - pathology</subject><subject>Olfactory Nerve - physiopathology</subject><subject>Otolaryngology</subject><subject>Patients</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Respiratory Tract Infections - complications</subject><subject>Rhinosinusitis</subject><subject>Science</subject><subject>Sensory Thresholds</subject><subject>Single photon emission computed tomography</subject><subject>Sinusitis - complications</subject><subject>Smell</subject><subject>Thallium</subject><subject>Thallium isotopes</subject><subject>Thallium Radioisotopes - administration & dosage</subject><subject>Thallium Radioisotopes - metabolism</subject><subject>Thallium-201</subject><subject>Thresholds</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Trauma</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUl2PEyEUnRiN-6H_wCiJL_sylY-BgReTTbNqkzUaXZ8JwzAtDQMVmJr-HX-pdNtdd41PXLjnHO49OVX1CsEZIi16tw5T9MrNNsGbGYS0ZS16Up0iQXDNMCRPH9Qn1VlK6wIinLHn1QkmDROwYafV78uUTEqj8RmEAQQ3KJ1D3AFv4taAbge-f72a39Sfvy2AHdXSgF82r4BXSTmQV8o5O401hgiofrTephxVtsED68GmVEU3HSh_pe24UTaOt60C06Hco02FlANYGeXyage2wU0-GxPTi-rZoFwyL4_nefXjw9XN_FN9_eXjYn55XWvawlz3zdBpBglumRCaIk67hvc9wn1LKVPUaAExaoahb3vVNUQooijqWygazDHm5Lx6c9DduJDk0d4kESGQc8wFK4jFAdEHtZabWAyJOxmUlbcPIS6litlqZ6QwUAwEatMZ3SihlaYdFIJzYXjDqSla74-_Td1oel3ciMo9En3c8XYll2ErCeUUQ1EELo4CMfycTMpytEkb55Q3YdrPjSgjjJE99O0_0P9v1xxQOoaUohnuh0FQ7iN3x5L7yMlj5Art9cNF7kl3GSN_AK2r2CY</recordid><startdate>20130228</startdate><enddate>20130228</enddate><creator>Shiga, Hideaki</creator><creator>Taki, Junichi</creator><creator>Washiyama, Kohshin</creator><creator>Yamamoto, Junpei</creator><creator>Kinase, Sakae</creator><creator>Okuda, Koichi</creator><creator>Kinuya, Seigo</creator><creator>Watanabe, Naoto</creator><creator>Tonami, Hisao</creator><creator>Koshida, Kichiro</creator><creator>Amano, Ryohei</creator><creator>Furukawa, Mitsuru</creator><creator>Miwa, Takaki</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130228</creationdate><title>Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers</title><author>Shiga, Hideaki ; Taki, Junichi ; Washiyama, Kohshin ; Yamamoto, Junpei ; Kinase, Sakae ; Okuda, Koichi ; Kinuya, Seigo ; Watanabe, Naoto ; Tonami, Hisao ; Koshida, Kichiro ; Amano, Ryohei ; Furukawa, Mitsuru ; Miwa, Takaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-d4fbc60327699c5185b48dd12d7556a5ec90214ffd7dab439a3a51d7094282283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Intranasal</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological Transport</topic><topic>Biology</topic><topic>Case-Control Studies</topic><topic>Chronic infection</topic><topic>Computed tomography</topic><topic>Correlation</topic><topic>Craniocerebral Trauma - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiga, Hideaki</au><au>Taki, Junichi</au><au>Washiyama, Kohshin</au><au>Yamamoto, Junpei</au><au>Kinase, Sakae</au><au>Okuda, Koichi</au><au>Kinuya, Seigo</au><au>Watanabe, Naoto</au><au>Tonami, Hisao</au><au>Koshida, Kichiro</au><au>Amano, Ryohei</au><au>Furukawa, Mitsuru</au><au>Miwa, Takaki</au><au>Hummel, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-02-28</date><risdate>2013</risdate><volume>8</volume><issue>2</issue><spage>e57671</spage><epage>e57671</epage><pages>e57671-e57671</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.
10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.
Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.
Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23469046</pmid><doi>10.1371/journal.pone.0057671</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-02, Vol.8 (2), p.e57671-e57671 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1330882896 |
| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central Free |
| subjects | Administration, Intranasal Adult Aged Biological Transport Biology Case-Control Studies Chronic infection Computed tomography Correlation Craniocerebral Trauma - complications Female Females Head injuries Hospitals Humans Infections Intranasal administration Magnetic Resonance Imaging Male Males Medical imaging Medical technology Medicine Middle Aged Migration NMR Nuclear magnetic resonance Object recognition Odor recognition Odor thresholds Odors Olfaction Olfaction Disorders - diagnostic imaging Olfaction Disorders - etiology Olfaction Disorders - metabolism Olfaction Disorders - physiopathology Olfactometers Olfactory bulb Olfactory Bulb - diagnostic imaging Olfactory Bulb - metabolism Olfactory Bulb - pathology Olfactory Bulb - physiopathology Olfactory nerve Olfactory Nerve - diagnostic imaging Olfactory Nerve - metabolism Olfactory Nerve - pathology Olfactory Nerve - physiopathology Otolaryngology Patients Respiratory tract Respiratory tract diseases Respiratory Tract Infections - complications Rhinosinusitis Science Sensory Thresholds Single photon emission computed tomography Sinusitis - complications Smell Thallium Thallium isotopes Thallium Radioisotopes - administration & dosage Thallium Radioisotopes - metabolism Thallium-201 Thresholds Tomography Tomography, Emission-Computed, Single-Photon Trauma |
| title | Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A37%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20olfactory%20nerve%20by%20SPECT-MRI%20image%20with%20nasal%20thallium-201%20administration%20in%20patients%20with%20olfactory%20impairments%20in%20comparison%20to%20healthy%20volunteers&rft.jtitle=PloS%20one&rft.au=Shiga,%20Hideaki&rft.date=2013-02-28&rft.volume=8&rft.issue=2&rft.spage=e57671&rft.epage=e57671&rft.pages=e57671-e57671&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0057671&rft_dat=%3Cproquest_plos_%3E2949769661%3C/proquest_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c570t-d4fbc60327699c5185b48dd12d7556a5ec90214ffd7dab439a3a51d7094282283%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1330882896&rft_id=info:pmid/23469046&rfr_iscdi=true |