Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study

Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD. For this pilot study, aqueous humor samples wer...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e56734-e56734
Main Authors: Jünemann, Anselm G M, Stopa, Piotr, Michalke, Bernhard, Chaudhri, Anwar, Reulbach, Udo, Huchzermeyer, Cord, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich E, Zrenner, Eberhart, Rejdak, Robert
Format: Article
Language:English
Subjects:
Age related diseases
Aged
Analysis
Aqueous Humor - metabolism
Biology
Cadmium
Care and treatment
Case-Control Studies
Cataracts
Cobalt
Copper
Eye surgery
Female
Humans
Inductively coupled plasma mass spectrometry
Iron
Kinases
Macular degeneration
Macular Degeneration - metabolism
Male
Manganese
Materials Science
Medical research
Medicine
Oxidative stress
Pathogenesis
Patients
Physiological aspects
Quality control
Quality management
Retina
Rodents
Selenium
Selenium (Chemical element)
Spectrometry
Surgery
Trace elements
Trace Elements - metabolism
Zinc
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Summary:Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD. For this pilot study, aqueous humor samples were collected from patients undergoing cataract surgery. 12 patients with dry AMD (age 77.9±6.62, female 8, male 4) and 11 patients without AMD (age 66.6±16.7, female 7, male 4) were included. Aqueous levels of cadmium, cobalt, copper, iron, manganese, selenium, and zinc were measured by use of Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry (FI-ICP-MS), quality controlled with certified standards. Patients with AMD had significantly higher aqueous humor levels of cadmium (median: 0.70 µmol/L, IQR: 0.40-0.84 vs. 0.06 µmol/L; IQR: 0.01-.018; p = 0.002), cobalt (median: 3.1 µmol/L, IQR: 2.62-3.15 vs. 1.17 µmol/L; IQR: 0.95-1.27; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0056734