Insulin-like growth factor receptor I (IGF-IR) and vascular endothelial growth factor receptor 2 (VEGFR-2) are expressed on the circulating epithelial tumor cells of breast cancer patients

Circulating epithelial tumor cell (CETC) analysis is a promising diagnostic field for estimating the risk for metastatic relapse and progression in patients with malignant disease. CETCs characterization can be used as a liquid biopsy for prognostic and predictive purposes in breast and other cancer...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e56836-e56836
Main Authors: Pizon, Monika, Zimon, Dorothea Sonja, Pachmann, Ulrich, Pachmann, Katharina
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Biology
Biopsy
Blood
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
Correlation
Diagnostic systems
Female
Gene expression
Humans
Immunohistochemistry
Insulin
Insulin-like growth factors
Kinases
Labeling
MCF-7 Cells
Medicine
Metastases
Metastasis
Middle Aged
Neoplasm Staging
Neoplastic Cells, Circulating - metabolism
Neoplastic Cells, Circulating - pathology
Patients
Receptor, IGF Type 1 - biosynthesis
Receptors
Statistical analysis
Tumor cells
Tumors
Vascular endothelial growth factor
Vascular endothelial growth factor receptor 2
Vascular Endothelial Growth Factor Receptor-2 - biosynthesis
Vascular endothelial growth factor receptors
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Summary:Circulating epithelial tumor cell (CETC) analysis is a promising diagnostic field for estimating the risk for metastatic relapse and progression in patients with malignant disease. CETCs characterization can be used as a liquid biopsy for prognostic and predictive purposes in breast and other cancers. IGF-IR and VEGFR-2 play an important role in tumor growth and the progression of cancer disease. The purpose of the current study was therefore to investigate their expression on CETCs. CETCs were determined from the blood of 50 patients suffering from breast cancer. The number of vital CETCs and the expression of IGF-IR and VEGFR-2 were investigated using the maintrac® method. IGF-IR and VEGFR-2 expression on the surface of CETCs were detected in 84% of patients. A statistically high correlation was found between IGF-IR and VEGFR-2 (r = 0.745 and p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0056836