TNFAIP3 gene polymorphisms in a Chinese Han population with Vogt-Koyanagi-Harada syndrome

• Published in: PloS one 2013-03, Vol.8 (3), p.e59515-e59515
• Main Authors: Li, Hong, Liu, Qing, Hou, Shengping, Du, Liping, Zhou, Qingyun, Zhou, Yan, Kijlstra, Aize, Yang, Peizeng
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Autoimmune diseases; Biology; Deoxyribonucleic acid; Disease; Disease control; DNA; DNA-Binding Proteins - genetics; Enzymes; Ethnic Groups - genetics; Female; Gene Frequency - genetics; Gene polymorphism; Genes; Genetic aspects; Genetic Predisposition to Disease - genetics; Genotypes; Hospitals; Humans; Intracellular Signaling Peptides and Proteins - genetics; Lupus; Lymphoma; Male; Medicine; Nuclear Proteins - genetics; Pathogenesis; Patients; Polymorphism; Polymorphism, Single Nucleotide; Population; Proteins; Psoriasis; Restriction fragment length polymorphism; Rheumatoid arthritis; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Tumor Necrosis Factor alpha-Induced Protein 3; Uveomeningoencephalitic Syndrome - ethnology; Uveomeningoencephalitic Syndrome - genetics
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0059515

This study was performed to evaluate the potential association of TNFAIP3 polymorphisms with Vogt-Koyanagi-Harada (VKH) disease in a Chinese Han population. Five single-nucleotide polymorphisms (SNPs), rs10499194, rs610604, rs7753873, rs5029928 and rs9494885 of TNFAIP3 were genotyped in 834 VKH disease patients and 1415 healthy controls using a PCR-restriction fragment length polymorphism assay. An increased frequency of the C allele and CT genotype for rs9494885 were found in VKH patients in the Guangzhou and Chongqing cohorts (pc = 0.015, OR = 1.6, pc = 0.036, OR = 1.7; pc = 2.36×10-4, OR = 1.5, pc = 0.012, OR = 1.5, respectively). Meanwhile, a decreased frequency of the TT genotype for rs9494885 was observed in VKH patients in the Guangzhou and Chongqing cohorts (pc = 0.026, OR = 0.6, pc = 0.0074, OR = 0.7, respectively). The combined analysis showed that a significantly increased prevalence of the rs9494885 TC genotype and C allele were found in VKH disease patients compared with controls (pc = 2.26×10-5, OR = 1.7; pc = 1.09× 10-5, OR = 1.6, respectively). The frequency of the TT genotype of rs9494885 was markedly lower in VKH disease patients as compared with that in controls (pc = 1.12×10-5, OR = 0.6; pc = 1.09×10(-5), OR = 0.6, respectively). No association was found between rs10499194, rs610604, rs7753873 and rs5029928 polymorphisms and VKH disease. To our knowledge this is the first report describing the association of a TNFAIP3 gene polymorphism with VKH disease in a Chinese Han population. The results suggest that the rs9494885 TC genotype and C allele may be predisposing factors to VKH disease, whereas the rs9494885 TT genotype and T allele may provide protection against this disease.