High-intensity endurance training results in faster vessel-specific rate of vasorelaxation in type 1 diabetic rats

• Published in: PloS one 2013-03, Vol.8 (3), p.e59678-e59678
• Main Authors: Murias, Juan M, Dey, Adwitia, Campos, Oscar A, Estaki, Mehrbod, Hall, Katharine E, Melling, Christopher W J, Noble, Earl G
• Format: Article
• Language: English
• Subjects: Acetylcholine; Analysis of Variance; Animals; Aorta; Aorta - physiology; Atherosclerosis; Biology; Blood vessels; Blotting, Western; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - physiopathology; Durability; Endothelium; Endurance; Exercise; Exponential functions; Femoral Artery - physiology; Femur; Fitness training programs; Glucose; Histological Techniques; Iliac Artery - physiology; Insulin; Kinesiology; Male; Medicine; Models, Biological; Musculoskeletal system; Nitric oxide; Nitric-oxide synthase; Nitrogen oxides; Physical Conditioning, Animal - physiology; Physical Endurance - physiology; Physical training; Pulmonary arteries; Rats; Rats, Sprague-Dawley; Resistance training; Rodents; Strength training; Training; Type 1 diabetes; Vasodilation; Vasodilation - physiology; Weight training; Western blotting
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0059678

This study examined the effects of 6 weeks of moderate- (MD) and high-intensity endurance training (HD) and resistance training (RD) on the vasorelaxation responsiveness of the aorta, iliac, and femoral vessels in type 1 diabetic (D) rats. Vasorelaxation to acetylcholine was modeled as a mono-exponential function. A potential mediator of vasorelaxation, endothelial nitric oxide synthase (e-NOS) was determined by Western blots. Vessel lumen-to-wall ratios were calculated from H&E stains. The vasorelaxation time-constant (τ) (s) was smaller in control (C) (7.2 ± 3.7) compared to D (9.1 ± 4.4) and it was smaller in HD (5.4 ± 1.5) compared to C, D, RD (8.3 ± 3.7) and MD (8.7 ± 3.8) (p