Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women

Association between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women. We collected data from participants residing in Jinchang district of...

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Published in:PloS one 2013-04, Vol.8 (4), p.e61159-e61159
Main Authors: Peng, Hao, Li, Hongmei, Li, Chao, Chao, Xiangqin, Zhang, Qiu, Zhang, Yonghong
Format: Article
Language:English
Subjects:
Acids
Adult
Aged
Alcohol use
Analysis
Asian Continental Ancestry Group
Bioindicators
Biomarkers
Biomarkers - blood
Blood Glucose - metabolism
Blood lipids
Diabetes mellitus
Disease prevention
Fasting
Female
Geriatrics
Humans
Hypertension
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - complications
Hyperuricemia - ethnology
Laboratories
Lipids
Lipids - blood
Medicine
Menopause
Middle Aged
Older people
Post-menopause
Postmenopausal women
Postmenopause - blood
Premenopause - blood
Regression Analysis
Risk Factors
Systematic review
Uric acid
Uric Acid - blood
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - ethnology
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Summary:Association between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women. We collected data from participants residing in Jinchang district of Suzhou from January to May, 2010. Serum uric acid, 25-hydroxy vitamin D and other traditional biomarkers including fasting plasma glucose and blood lipids were determined in 1726 women aged above 30 years. Association between vitamin D insufficiency and elevated uric acid was analyzed in premenopausal and postmenopausal women, respectively. Among postmenopausal women, 25-hydroxy vitamin D level of participants with elevated uric acid was lower than that of those with normal uric acid (median [interquartile range]: 35[28-57] vs 40[32-58], µg/L; P = 0.006). Elevated uric acid was more prevalent in participants with vitamin D insufficiency compared to those without vitamin D insufficiency (16.50% vs 8.08%; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061159