Real-time 3-dimensional echocardiographic assessment of ventricular volume, mass, and function in human fetuses

We sought to determine the feasibility and reproducibility of real-time 3-dimensional echocardiography (RT3DE) for evaluation of cardiac volume, mass, and function and to characterize maturational changes of these measurements in human fetuses. Eighty pregnant women in the 2(nd) and 3(rd) trimesters...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e58494-e58494
Main Authors: Zheng, Minjuan, Schaal, Micheal, Chen, Yan, Li, Xiaokui, Shentu, Weihui, Zhang, Pengyuan, Ashraf, Muhammad, Ge, Shuping, Sahn, David J
Format: Article
Language:English
Subjects:
Accuracy
Adolescent
Adult
Age
Analysis
Cardiac output
Cardiology
Chronology
Congenital heart defects
Coronary artery disease
Datasets
Diagnosis
Echocardiography
Echocardiography, Three-Dimensional - methods
Feasibility Studies
Female
Fetus - physiology
Fetuses
Genetic disorders
Gestational age
Heart
Heart diseases
Heart Ventricles - embryology
Hospitals
Humans
Image acquisition
Medicine
Observer Variation
Obstetrics
Organ Size
Pediatrics
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Real time
Reproducibility
Reproducibility of Results
Science
Stroke
Stroke volume
Time Factors
Ultrasonic imaging
Ventricle
Ventricular Function - physiology
Young Adult
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Summary:We sought to determine the feasibility and reproducibility of real-time 3-dimensional echocardiography (RT3DE) for evaluation of cardiac volume, mass, and function and to characterize maturational changes of these measurements in human fetuses. Eighty pregnant women in the 2(nd) and 3(rd) trimesters (59 with normal fetuses and 21 with fetuses with congenital heart disease [CHD]) were enrolled. We acquired RT3DE images using a matrix-array transducer. RT3DE measurements of volume, mass, stroke volume (SV), combined cardiac output (CCO), and ejection fraction (EF) were obtained. Images were scored and analyzed by two blinded independent observers. Inter- and intraobserver variabilities and correlations between fetal cardiac indices and gestational age were determined. Fifty-two of 59 normal data sets (88%) and 9 of 21 CHD data sets (43%) were feasible for analysis. In normal fetuses, the right ventricle (RV) is larger than the left ventricle (LV) (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0058494