Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma

While several studies have examined the general inflammatory responses in relation to cytomegalovirus infection, the identification of the various inflammatory mediators as well as their relative importance is far from clear. Solid organ recipients enrolled in an international multicenter trial of c...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e60767-e60767
Main Authors: Rollag, Halvor, Ueland, Thor, Asberg, Anders, Hartmann, Anders, Jardine, Alan G, Humar, Atul, Pescovitz, Mark D, Bignamini, Angelo A, Aukrust, Pål
Format: Article
Language:English
Subjects:
Adult
Analysis
Antigens
Arthritis
Biological response modifiers
Biology
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Cell activation
Chemokines
Chemokines - blood
CXC chemokines
Cytokines
Cytomegalovirus
Cytomegalovirus - physiology
Cytomegalovirus infections
Cytomegalovirus Infections - blood
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - immunology
Deoxyribonucleic acid
DNA
Endothelial cells
Enzymes
Female
Gastroenterology
Hospitals
Humans
Immune system
Immunoassays
Immunology
Infection
Infections
Infectious diseases
Inflammation
Inflammation - blood
Interferon
Interferon-inducible protein
Internal medicine
Laboratories
Male
Markers
Medical research
Medical treatment
Medicine
Middle Aged
Multivariate Analysis
Nephrology
Organ transplant recipients
Organ transplantation
Pentraxins
Pharmacy
Plasma levels
Proteins
Studies
Transplants
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While several studies have examined the general inflammatory responses in relation to cytomegalovirus infection, the identification of the various inflammatory mediators as well as their relative importance is far from clear. Solid organ recipients enrolled in an international multicenter trial of cytomegalovirus disease treatment (the VICTOR study) were analyzed (n = 289) (ClinicalTrials.gov NCT00431353). Plasma markers of inflammation and endothelial cell activation were assessed at baseline by enzyme immunoassays. The major findings were: (i) Plasma levels of the CXC-chemokine interferon-inducible protein-10 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060767