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CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties
Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant dif...
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| Published in: | PloS one 2013-03, Vol.8 (3), p.e59354-e59354 |
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| container_end_page | e59354 |
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| creator | Yang, Zhou Xin Han, Zhi-Bo Ji, Yue Ru Wang, You Wei Liang, Lu Chi, Ying Yang, Shao Guang Li, Li Na Luo, Wei Feng Li, Jian Ping Chen, Dan Dan Du, Wen Jing Cao, Xiao Cang Zhuo, Guang Sheng Wang, Tao Han, Zhong Chao |
| description | Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs. |
| doi_str_mv | 10.1371/journal.pone.0059354 |
| format | article |
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MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0059354</identifier><identifier>PMID: 23555021</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipocytes - cytology ; Adipocytes - immunology ; Adipose Tissue - cytology ; Adipose Tissue - immunology ; Adult ; B cells ; Biocompatibility ; Biological properties ; Biology ; Biomarkers - metabolism ; Biomedical materials ; Blood diseases ; Bone marrow ; Bone Marrow Cells - cytology ; Bone Marrow Cells - immunology ; Cell adhesion & migration ; Cell Differentiation ; Cell self-renewal ; Chorion - cytology ; Chorion - immunology ; Cytokines ; Cytokines - biosynthesis ; Cytokines - immunology ; Dendritic cells ; Differentiation ; Engineering research ; Female ; Gene Expression ; Hematology ; Hospitals ; Humans ; Immunomodulation ; Immunoregulation ; Immunosuppressive agents ; Laboratories ; Mathematics ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - classification ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - immunology ; Mesenchyme ; Osteocytes - cytology ; Osteocytes - immunology ; Placenta ; Pregnancy ; Rodents ; Stem cells ; Subpopulations ; T-Lymphocytes, Helper-Inducer - cytology ; T-Lymphocytes, Helper-Inducer - immunology ; Tissues ; Tumor necrosis factor-TNF ; Umbilical cord ; Umbilical Cord - cytology ; Umbilical Cord - immunology ; Vascular cell adhesion molecule 1 ; Vascular Cell Adhesion Molecule-1 - genetics ; Vascular Cell Adhesion Molecule-1 - immunology</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e59354-e59354</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Yang et al 2013 Yang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1546846fbbb4bbf4e17a0b9a26969d4cd162410718fd5ccf5cc43295772c03e33</citedby><cites>FETCH-LOGICAL-c692t-1546846fbbb4bbf4e17a0b9a26969d4cd162410718fd5ccf5cc43295772c03e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1330898813/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1330898813?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23555021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vergani, Andrea</contributor><creatorcontrib>Yang, Zhou Xin</creatorcontrib><creatorcontrib>Han, Zhi-Bo</creatorcontrib><creatorcontrib>Ji, Yue Ru</creatorcontrib><creatorcontrib>Wang, You Wei</creatorcontrib><creatorcontrib>Liang, Lu</creatorcontrib><creatorcontrib>Chi, Ying</creatorcontrib><creatorcontrib>Yang, Shao Guang</creatorcontrib><creatorcontrib>Li, Li Na</creatorcontrib><creatorcontrib>Luo, Wei Feng</creatorcontrib><creatorcontrib>Li, Jian Ping</creatorcontrib><creatorcontrib>Chen, Dan Dan</creatorcontrib><creatorcontrib>Du, Wen Jing</creatorcontrib><creatorcontrib>Cao, Xiao Cang</creatorcontrib><creatorcontrib>Zhuo, Guang Sheng</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Han, Zhong Chao</creatorcontrib><title>CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - immunology</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - immunology</subject><subject>Adult</subject><subject>B cells</subject><subject>Biocompatibility</subject><subject>Biological properties</subject><subject>Biology</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical materials</subject><subject>Blood diseases</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - immunology</subject><subject>Cell adhesion & migration</subject><subject>Cell Differentiation</subject><subject>Cell self-renewal</subject><subject>Chorion - cytology</subject><subject>Chorion - immunology</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - immunology</subject><subject>Dendritic cells</subject><subject>Differentiation</subject><subject>Engineering research</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunomodulation</subject><subject>Immunoregulation</subject><subject>Immunosuppressive agents</subject><subject>Laboratories</subject><subject>Mathematics</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - classification</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - immunology</subject><subject>Mesenchyme</subject><subject>Osteocytes - cytology</subject><subject>Osteocytes - immunology</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Rodents</subject><subject>Stem cells</subject><subject>Subpopulations</subject><subject>T-Lymphocytes, Helper-Inducer - cytology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Tissues</subject><subject>Tumor necrosis factor-TNF</subject><subject>Umbilical cord</subject><subject>Umbilical Cord - cytology</subject><subject>Umbilical Cord - immunology</subject><subject>Vascular cell adhesion molecule 1</subject><subject>Vascular Cell Adhesion Molecule-1 - genetics</subject><subject>Vascular Cell Adhesion Molecule-1 - immunology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjPluciMs49fAwoJftyFJ02mGtqlJq86_N3W6y1T2QkppSZ_3zcnbc7LsKQRriAv4Zu_H0Klm3fvOrgGgAlNyLzuHAqMVQwDfP3k_yx7FuE8Q5ow9zM4QppQCBM8zvXkHActdabvBVc7GXOVx1L3vx0YNzne5r_LWRtuZ-tCqJo-DbXNjmybmv9xQ52Pnfow2d207dr715STz4ZD3wfc2DMnxcfagUk20T-bnRfbtw_uvm0-rq-uP283l1cowgYYVpIRxwiqtNdG6IhYWCmihEBNMlMSUkCECQQF5VVJjqnQTjAQtCmQAthhfZM-Pvn3jo5zjiRJiDLjgHE7E9kiUXu1lH1yrwkF65eTfBR92UqWSTWOl0MhaZiqlC0W0QEpTLFRhDNSAUE6S19t5t1G3tjQpv6CahenyS-dqufM_JaaCIo6SwavZIPiUYBxk6-IUrOqsH6e6EcGcgwIk9MU_6N2nm6mdSgdwXeXTvmYylZek4BhAQKa613dQ6Spt60zqpcql9YXg9UKQmMH-HnZqjFFuv3z-f_b6-5J9ecLWVjVDHX0zTk0XlyA5gib4GIOtbkOGQE6jcJOGnEZBzqOQZM9Of9Ct6Kb38R9gHwSC</recordid><startdate>20130312</startdate><enddate>20130312</enddate><creator>Yang, Zhou Xin</creator><creator>Han, Zhi-Bo</creator><creator>Ji, Yue Ru</creator><creator>Wang, You Wei</creator><creator>Liang, Lu</creator><creator>Chi, Ying</creator><creator>Yang, Shao Guang</creator><creator>Li, Li Na</creator><creator>Luo, Wei Feng</creator><creator>Li, Jian Ping</creator><creator>Chen, Dan Dan</creator><creator>Du, Wen Jing</creator><creator>Cao, Xiao Cang</creator><creator>Zhuo, Guang Sheng</creator><creator>Wang, Tao</creator><creator>Han, Zhong Chao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130312</creationdate><title>CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties</title><author>Yang, Zhou Xin ; Han, Zhi-Bo ; Ji, Yue Ru ; Wang, You Wei ; Liang, Lu ; Chi, Ying ; Yang, Shao Guang ; Li, Li Na ; Luo, Wei Feng ; Li, Jian Ping ; Chen, Dan Dan ; Du, Wen Jing ; Cao, Xiao Cang ; Zhuo, Guang Sheng ; Wang, Tao ; Han, Zhong Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1546846fbbb4bbf4e17a0b9a26969d4cd162410718fd5ccf5cc43295772c03e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipocytes - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zhou Xin</au><au>Han, Zhi-Bo</au><au>Ji, Yue Ru</au><au>Wang, You Wei</au><au>Liang, Lu</au><au>Chi, Ying</au><au>Yang, Shao Guang</au><au>Li, Li Na</au><au>Luo, Wei Feng</au><au>Li, Jian Ping</au><au>Chen, Dan Dan</au><au>Du, Wen Jing</au><au>Cao, Xiao Cang</au><au>Zhuo, Guang Sheng</au><au>Wang, Tao</au><au>Han, Zhong Chao</au><au>Vergani, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-12</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e59354</spage><epage>e59354</epage><pages>e59354-e59354</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23555021</pmid><doi>10.1371/journal.pone.0059354</doi><tpages>e59354</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-03, Vol.8 (3), p.e59354-e59354 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1330898813 |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Adipocytes - cytology Adipocytes - immunology Adipose Tissue - cytology Adipose Tissue - immunology Adult B cells Biocompatibility Biological properties Biology Biomarkers - metabolism Biomedical materials Blood diseases Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - immunology Cell adhesion & migration Cell Differentiation Cell self-renewal Chorion - cytology Chorion - immunology Cytokines Cytokines - biosynthesis Cytokines - immunology Dendritic cells Differentiation Engineering research Female Gene Expression Hematology Hospitals Humans Immunomodulation Immunoregulation Immunosuppressive agents Laboratories Mathematics Mesenchymal stem cells Mesenchymal Stromal Cells - classification Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - immunology Mesenchyme Osteocytes - cytology Osteocytes - immunology Placenta Pregnancy Rodents Stem cells Subpopulations T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology Tissues Tumor necrosis factor-TNF Umbilical cord Umbilical Cord - cytology Umbilical Cord - immunology Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - immunology |
| title | CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties |
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