Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola

Host resistance and synthetic antimicrobials such as fungicides are two of the main approaches used to control plant diseases in conventional agriculture. Although pathogens often evolve to overcome host resistance and antimicrobials, the majority of reports have involved qualitative host - pathogen...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e59568
Main Authors: Yang, Lina, Gao, Fangluan, Shang, Liping, Zhan, Jiasui, McDonald, Bruce A
Format: Article
Language:English
Subjects:
Agricultural management
Agriculture
Antimicrobial agents
Antimicrobial resistance
Ascomycota - drug effects
Ascomycota - pathogenicity
Biology
Biosynthesis
Continents
Disease control
Drug resistance
Drug Resistance, Fungal
Epidemics
Evolution
Fungi
Fungicides
Fungicides, Industrial - pharmacology
Health aspects
Host plants
Infections
Kinases
Laboratories
Medicine
Metabolites
Microbial drug resistance
Mutation
Mycosphaerella graminicola
Parasitic diseases
Pathogens
Pesticides
Phytopathogenic fungi
Plant diseases
Plant Leaves - microbiology
Plants - microbiology
Proteins
Studies
Triazoles
Triazoles - pharmacology
Virology
Virulence
Virulence (Microbiology)
Wheat
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Summary:Host resistance and synthetic antimicrobials such as fungicides are two of the main approaches used to control plant diseases in conventional agriculture. Although pathogens often evolve to overcome host resistance and antimicrobials, the majority of reports have involved qualitative host - pathogen interactions or antimicrobials targeting a single pathogen protein or metabolic pathway. Studies that consider jointly the evolution of virulence, defined as the degree of damage caused to a host by parasite infection, and antimicrobial resistance are rare. Here we compared virulence and fungicide tolerance in the fungal pathogen Mycosphaerella graminicola sampled from wheat fields across three continents and found a positive correlation between virulence and tolerance to a triazole fungicide. We also found that quantitative host resistance selected for higher pathogen virulence. The possible mechanisms responsible for these observations and their consequences for sustainable disease management are discussed.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0059568