Stress within a restricted time window selectively affects the persistence of long-term memory

• Published in: PloS one 2013-03, Vol.8 (3), p.e59075
• Main Authors: Yang, Chang, Liu, Jian-Feng, Chai, Bai-Sheng, Fang, Qin, Chai, Ning, Zhao, Li-Yan, Xue, Yan-Xue, Luo, Yi-Xiao, Jian, Min, Han, Ying, Shi, Hai-Shui, Lu, Lin, Wu, Ping, Wang, Ji-Shi
• Format: Article
• Language: English
• Subjects: Animal behavior; Animal memory; Animals; Biology; Cold; Cold water; Conditioning (Psychology) - drug effects; Consolidation; Corticosterone; Corticosterone - administration & dosage; Corticosterone - pharmacology; Emotions; Fear - drug effects; Glucocorticoids; Kinases; Long term memory; Male; Medicine; Memory, Long-Term - drug effects; Mental Recall - drug effects; Metyrapone - pharmacology; Pharmacy; Protein biosynthesis; Protein synthesis; Rats; Rats, Sprague-Dawley; Retrieval; Rodents; Social and Behavioral Sciences; Stress, Physiological - drug effects; Time Factors; Variance analysis; Water stress; Windows (intervals)
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0059075

The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM) formation (tested 24 h later), but the effects of stress on the persistence of LTM (tested at least 1 week later) are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress) during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h) after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h) after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system.