Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy

Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in ou...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e59215-e59215
Main Authors: Sierra, Josep M, Camoez, Mariana, Tubau, Fe, Gasch, Oriol, Pujol, Miquel, Martin, Rogelio, Domínguez, M Angeles
Format: Article
Language:English
Subjects:
Acetamides - therapeutic use
Aged
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - metabolism
Biology
Case reports
Clinical isolates
Clinical medicine
Cloning
Drug resistance
Drug Resistance, Multiple, Bacterial
Epidemics
Genes
Hospitals
Humans
Infeccions respiratòries
Infectious diseases
Intensive care
Intensive care units
Linezolid
Male
Medicine
Methicillin
Methicillin - therapeutic use
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Methicillin-Resistant Staphylococcus aureus - metabolism
Microbial drug resistance
Microbial Sensitivity Tests
Microbiology
Mutation
Oxazolidinones - therapeutic use
Pathology
Patients
Respiratory infections
Spain
Staphylococcal infections
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus infections
Therapy
Unitats de cures intensives
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Summary:Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0059215