Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer

The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatm...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e60268-e60268
Main Authors: Nguyen, Nam P, Ceizyk, Misty, Vos, Paul, Betz, Michael, Chi, Alexander, Almeida, Fabio, Davis, Rick, Slane, Benjamin, Gelumbauskas, Steven, Smith-Raymond, Lexie, Abraham, Dave, Stevie, Michelle, Jang, Siyoung, Vinh-Hung, Vincent
Format: Article
Language:English
Subjects:
Acute toxicity
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biology
Cancer
Cancer therapies
Chemoradiotherapy
Cisplatin - therapeutic use
Clinical trials
Complications
Dysphagia
Feasibility studies
Female
Head & neck cancer
Humans
Lymphatic system
Male
Medical diagnosis
Medical imaging
Medicine
Metastases
Middle Aged
Mucositis
Oncology
Organs
Oropharyngeal cancer
Oropharyngeal Neoplasms - drug therapy
Oropharyngeal Neoplasms - therapy
Patients
Radiation
Radiation dosage
Radiation therapy
Radiotherapy, Image-Guided - methods
Regional analysis
Regional development
Regional planning
Retrospective Studies
Throat cancer
Tissues
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatment toxicity and loco-regional control were assessed. At a median follow-up of 32 months (6-47 months), no patient developed loco-regional recurrence. Two patients (6%) developed distant metastases. Grade 3-4 acute toxicity was respectively 72% and 25% for mucositis and gastrointestinal toxicity. Two patients (6%) had long-term dependence on tube feedings. Dose-volume histogram demonstrated excellent target volume coverage and low radiation dose to the organs at risk for complications. IGRT provides excellent loco-regional control but acute toxicity remains significant and needs to be addressed in future prospective trials. The feasibility of Tomotherapy to decrease radiation dose to the normal tissues merits further investigations.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060268