Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer

The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatm...

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Published in:PloS one 2013-03, Vol.8 (3), p.e60268-e60268
Main Authors: Nguyen, Nam P, Ceizyk, Misty, Vos, Paul, Betz, Michael, Chi, Alexander, Almeida, Fabio, Davis, Rick, Slane, Benjamin, Gelumbauskas, Steven, Smith-Raymond, Lexie, Abraham, Dave, Stevie, Michelle, Jang, Siyoung, Vinh-Hung, Vincent
Format: Article
Language:English
Subjects:
Acute toxicity
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biology
Cancer
Cancer therapies
Chemoradiotherapy
Cisplatin - therapeutic use
Clinical trials
Complications
Dysphagia
Feasibility studies
Female
Head & neck cancer
Humans
Lymphatic system
Male
Medical diagnosis
Medical imaging
Medicine
Metastases
Middle Aged
Mucositis
Oncology
Organs
Oropharyngeal cancer
Oropharyngeal Neoplasms - drug therapy
Oropharyngeal Neoplasms - therapy
Patients
Radiation
Radiation dosage
Radiation therapy
Radiotherapy, Image-Guided - methods
Regional analysis
Regional development
Regional planning
Retrospective Studies
Throat cancer
Tissues
Toxicity
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cited_by cdi_FETCH-LOGICAL-c526t-7fac1f7c6ffc05e99bb5a284534cc91bd5a6d58b2ace9d89c474297d7f49d66f3
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container_title PloS one
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creator Nguyen, Nam P
Ceizyk, Misty
Vos, Paul
Betz, Michael
Chi, Alexander
Almeida, Fabio
Davis, Rick
Slane, Benjamin
Gelumbauskas, Steven
Smith-Raymond, Lexie
Abraham, Dave
Stevie, Michelle
Jang, Siyoung
Vinh-Hung, Vincent
description The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatment toxicity and loco-regional control were assessed. At a median follow-up of 32 months (6-47 months), no patient developed loco-regional recurrence. Two patients (6%) developed distant metastases. Grade 3-4 acute toxicity was respectively 72% and 25% for mucositis and gastrointestinal toxicity. Two patients (6%) had long-term dependence on tube feedings. Dose-volume histogram demonstrated excellent target volume coverage and low radiation dose to the organs at risk for complications. IGRT provides excellent loco-regional control but acute toxicity remains significant and needs to be addressed in future prospective trials. The feasibility of Tomotherapy to decrease radiation dose to the normal tissues merits further investigations.
doi_str_mv 10.1371/journal.pone.0060268
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1932-6203
language eng
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source Publicly Available Content Database; PubMed Central
subjects Acute toxicity
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biology
Cancer
Cancer therapies
Chemoradiotherapy
Cisplatin - therapeutic use
Clinical trials
Complications
Dysphagia
Feasibility studies
Female
Head & neck cancer
Humans
Lymphatic system
Male
Medical diagnosis
Medical imaging
Medicine
Metastases
Middle Aged
Mucositis
Oncology
Organs
Oropharyngeal cancer
Oropharyngeal Neoplasms - drug therapy
Oropharyngeal Neoplasms - therapy
Patients
Radiation
Radiation dosage
Radiation therapy
Radiotherapy, Image-Guided - methods
Regional analysis
Regional development
Regional planning
Retrospective Studies
Throat cancer
Tissues
Toxicity
title Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer
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