Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes

Rupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS) and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of...

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Published in:PloS one 2012-02, Vol.7 (2), p.e31136-e31136
Main Authors: Menon, Ramkumar, Yu, Jie, Basanta-Henry, Patrice, Brou, Lina, Berga, Sarah L, Fortunato, Stephen J, Taylor, Robert N
Format: Article
Language:English
Subjects:
African Americans
Apoptosis
Atherosclerosis
Biochemistry
Biology
Cell cycle
Cell division
Childbirth & labor
Chromosomes
Cord blood
Correlation
Correlation analysis
Correlation coefficient
Correlation coefficients
Deoxyribonucleic acid
Diabetes
DNA
DNA damage
Epidemiology
Female
Fetal Blood
Fetal Membranes, Premature Rupture - etiology
Fetal Membranes, Premature Rupture - pathology
Fetuses
Gestation
Gestational Age
Gynecology
Health aspects
Humans
Infections
Insulin resistance
Leukocytes
Leukocytes - ultrastructure
Medicine
Membranes
Mortality
Obstetrics
Oxidative Stress
Placenta
Polymerase Chain Reaction
Pregnancy
Premature Birth
Premature infants
Racial differences
Review boards
Risk factors
Rupture
Senescence
Telomerase
Telomere - ultrastructure
Telomeres
Variance analysis
Womens health
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Fortunato, Stephen J
Taylor, Robert N
description Rupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS) and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of the membranes (pPROM) or spontaneous preterm births with intact membranes (PTB), compared to term birth. Telomere lengths were quantified in cord blood leukocytes (n = 133) from three major groups: 1) pPROM (n = 28), 2) PTB (n = 69) and 3) uncomplicated full term births (controls, n = 35), using real-time quantitative PCR. Placental membrane specimens (n = 18) were used to correlate fetal leukocyte and placental telomere lengths. Telomere length differences among the groups were analyzed by ANOVA. Pearson correlation coefficients determined relationships between leukocyte and placental membrane telomere lengths. In pregnancies with intact membranes, fetal leukocyte telomere length was inversely proportional to gestational age. The mean telomere length decreased as gestation progressed, with the shortest at term. pPROM had telomere lengths (9962 ± 3124 bp) that were significantly shorter than gestational age-matched PTB (11546 ± 4348 bp, p = 0.04), but comparable to term births (9011 ± 2497 bp, p = 0.31). Secondary analyses revealed no effects of race (African American vs. Caucasian) or intraamniotic infection on telomere length. A strong Pearson's correlation was noted between fetal leukocyte and placental membrane telomere lengths (ρ = 0.77; p
doi_str_mv 10.1371/journal.pone.0031136
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Telomere shortening is a surrogate for oxidative stress (OS) and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of the membranes (pPROM) or spontaneous preterm births with intact membranes (PTB), compared to term birth. Telomere lengths were quantified in cord blood leukocytes (n = 133) from three major groups: 1) pPROM (n = 28), 2) PTB (n = 69) and 3) uncomplicated full term births (controls, n = 35), using real-time quantitative PCR. Placental membrane specimens (n = 18) were used to correlate fetal leukocyte and placental telomere lengths. Telomere length differences among the groups were analyzed by ANOVA. Pearson correlation coefficients determined relationships between leukocyte and placental membrane telomere lengths. In pregnancies with intact membranes, fetal leukocyte telomere length was inversely proportional to gestational age. 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Telomere shortening is a surrogate for oxidative stress (OS) and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of the membranes (pPROM) or spontaneous preterm births with intact membranes (PTB), compared to term birth. Telomere lengths were quantified in cord blood leukocytes (n = 133) from three major groups: 1) pPROM (n = 28), 2) PTB (n = 69) and 3) uncomplicated full term births (controls, n = 35), using real-time quantitative PCR. Placental membrane specimens (n = 18) were used to correlate fetal leukocyte and placental telomere lengths. Telomere length differences among the groups were analyzed by ANOVA. Pearson correlation coefficients determined relationships between leukocyte and placental membrane telomere lengths. In pregnancies with intact membranes, fetal leukocyte telomere length was inversely proportional to gestational age. The mean telomere length decreased as gestation progressed, with the shortest at term. pPROM had telomere lengths (9962 ± 3124 bp) that were significantly shorter than gestational age-matched PTB (11546 ± 4348 bp, p = 0.04), but comparable to term births (9011 ± 2497 bp, p = 0.31). Secondary analyses revealed no effects of race (African American vs. Caucasian) or intraamniotic infection on telomere length. A strong Pearson's correlation was noted between fetal leukocyte and placental membrane telomere lengths (ρ = 0.77; p&lt;0.01). Fetal leukocyte telomere length is reduced in pPROM compared to PTB but is similar to term births. pPROM represents a placental membrane disease likely mediated by OS-induced senescence.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22348044</pmid><doi>10.1371/journal.pone.0031136</doi><tpages>e31136</tpages><oa>free_for_read</oa></addata></record>
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source Publicly Available Content (ProQuest); PubMed Central
subjects African Americans
Apoptosis
Atherosclerosis
Biochemistry
Biology
Cell cycle
Cell division
Childbirth & labor
Chromosomes
Cord blood
Correlation
Correlation analysis
Correlation coefficient
Correlation coefficients
Deoxyribonucleic acid
Diabetes
DNA
DNA damage
Epidemiology
Female
Fetal Blood
Fetal Membranes, Premature Rupture - etiology
Fetal Membranes, Premature Rupture - pathology
Fetuses
Gestation
Gestational Age
Gynecology
Health aspects
Humans
Infections
Insulin resistance
Leukocytes
Leukocytes - ultrastructure
Medicine
Membranes
Mortality
Obstetrics
Oxidative Stress
Placenta
Polymerase Chain Reaction
Pregnancy
Premature Birth
Premature infants
Racial differences
Review boards
Risk factors
Rupture
Senescence
Telomerase
Telomere - ultrastructure
Telomeres
Variance analysis
Womens health
title Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes
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