Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US

Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8-12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full...

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Bibliographic Details
Published in:PloS one 2012-02, Vol.7 (2), p.e32739-e32739
Main Authors: Pinto, Pierfrancesco, Wang, Qiuhong, Chen, Ning, Dubovi, Edward J, Daniels, Joshua B, Millward, Laurie M, Buonavoglia, Canio, Martella, Vito, Saif, Linda J
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Animals
Biology
Caliciviridae Infections - virology
Capsid protein
Cats
Cats - virology
Diagnostic software
Diagnostic systems
Diarrhea
Enteritis
Epidemiology
Experimental infection
Feces
Gastroenteritis
Gastroenteritis - virology
Genetic aspects
Genetic diversity
Genome, Viral - genetics
Genomes
Health care
Host range
Infections
Norovirus - genetics
Norovirus - pathogenicity
Outbreaks
Pathogenesis
Prevention
Preventive medicine
Public health
Respiratory diseases
Ribonucleic acid
RNA
RNA polymerase
Shelters
Veterinary Science
Viral proteins
Viruses
VP1 protein
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Description
Summary:Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8-12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs: lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0032739