Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients

Recent studies have suggested that deregulated AKT1 signaling is associated with schizophrenia. We hypothesized that if this is indeed the case, we should observe both decreased AKT1 expression as well as deregulation of AKT1 regulated pathways in Peripheral Blood Mononuclear Cells (PBMCs) of schizo...

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Bibliographic Details
Published in:PloS one 2012-02, Vol.7 (2), p.e32618-e32618
Main Authors: van Beveren, Nico J M, Buitendijk, Gabrielle H S, Swagemakers, Sigrid, Krab, Lianne C, Röder, Christian, de Haan, Lieuwe, van der Spek, Peter, Elgersma, Ype
Format: Article
Language:English
Subjects:
Adult
Age of Onset
AKT protein
AKT1 protein
Antipsychotics
Apoptosis
Axon guidance
Biological activity
Biology
Biotinylation
Bipolar disorder
Blood
Case-Control Studies
Cell Adhesion
Cell Cycle
Comparative analysis
Control methods
Deregulation
Functional analysis
Gene expression
Gene Expression Regulation, Enzymologic
Genes
Genetic Predisposition to Disease
Genome
Genomes
Genomics
Glucose metabolism
Growth factors
Humans
Immune system
Insulin resistance
Kinases
Leukocytes (mononuclear)
Leukocytes, Mononuclear - cytology
Male
Medicine
Mental disorders
Metabolism
Models, Biological
Neurotrophic factors
Oxidative metabolism
Oxidative stress
Patients
Peripheral blood mononuclear cells
Proto-Oncogene Proteins c-akt - metabolism
Schizophrenia
Schizophrenia - enzymology
Schizophrenia - metabolism
Software development tools
Studies
Toxoplasma gondii
Type 2 diabetes
Variance analysis
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Summary:Recent studies have suggested that deregulated AKT1 signaling is associated with schizophrenia. We hypothesized that if this is indeed the case, we should observe both decreased AKT1 expression as well as deregulation of AKT1 regulated pathways in Peripheral Blood Mononuclear Cells (PBMCs) of schizophrenia patients. To examine PBMC expression levels of AKT1 in schizophrenia patients versus controls, and to examine whether functional biological processes in which AKT1 plays an important role are deregulated in schizophrenia patients. A case-control study, investigating whole-genome PBMC gene expression in male, recent onset (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0032618