Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes

The objectives of this study were to analyse the effect of heart failure (HF) on several proteins of nuclear pore complex (NPC) and their relationship with the human ventricular function. A total of 88 human heart samples from ischemic (ICM, n = 52) and dilated (DCM, n = 36) patients undergoing hear...

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Published in:PloS one 2012-11, Vol.7 (11), p.e48957-e48957
Main Authors: Tarazón, Estefanía, Rivera, Miguel, Roselló-Lletí, Esther, Molina-Navarro, Maria Micaela, Sánchez-Lázaro, Ignacio José, España, Francisco, Montero, José Anastasio, Lago, Francisca, González-Juanatey, José Ramón, Portolés, Manuel
Format: Article
Language:English
Subjects:
Adult
Alcohol
Biology
Biomedical research
Cardiology
Cardiomyocytes
Cardiomyopathy
Ethics
Etiology
Female
Fluorescence
Heart
Heart diseases
Heart failure
Heart Failure - etiology
Heart Failure - metabolism
Heart transplantation
Heart Ventricles - metabolism
Heart Ventricles - physiopathology
Hospitals
Humans
Immunocytochemistry
Ischemia
Male
Medicine
Middle Aged
Monoclonal antibodies
Mutation
Myocytes, Cardiac - metabolism
Nuclear Pore Complex Proteins - metabolism
Nuclear Proteins - metabolism
Nuclei
Nuclei (cytology)
Nucleoporins
Protein Transport
Proteins
Transplants & implants
Values
Ventricle
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Summary:The objectives of this study were to analyse the effect of heart failure (HF) on several proteins of nuclear pore complex (NPC) and their relationship with the human ventricular function. A total of 88 human heart samples from ischemic (ICM, n = 52) and dilated (DCM, n = 36) patients undergoing heart transplant and control donors (CNT, n = 9) were analyzed by Western blot. Subcellular distribution of nucleoporins was analysed by fluorescence and immunocytochemistry. When we compared protein levels according to etiology, ICM showed significant higher levels of NDC1 (65%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0048957