Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis

Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum conversion. Induced sputum was collected from 68 TB patients...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e61333-e61333
Main Authors: Ugarte-Gil, Cesar A, Elkington, Paul, Gilman, Robert H, Coronel, Jorge, Tezera, Liku B, Bernabe-Ortiz, Antonio, Gotuzzo, Eduardo, Friedland, Jon S, Moore, David A J
Format: Article
Language:English
Subjects:
Adult
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Asthma
Care and treatment
Case-Control Studies
Chronic obstructive pulmonary disease
Cross-Sectional Studies
Culture Techniques
Enzyme-linked immunosorbent assay
Epidemiology
Extracellular matrix
Female
Gelatinase A
HIV
Human immunodeficiency virus
Humans
Immunology
Infections
Infectious diseases
Interstitial collagenase
Longitudinal Studies
Lungs
Male
Matrix metalloproteinase
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 3 - metabolism
Matrix Metalloproteinase 8 - metabolism
Matrix metalloproteinases
Matrix Metalloproteinases, Secreted - metabolism
Medical diagnosis
Medical research
Medicine
Mortality
Mycobacterium tuberculosis
Patients
Public health
Sputum
Sputum - drug effects
Sputum - enzymology
Sputum - metabolism
Tissue inhibitor of metalloproteinase 1
Tissue inhibitor of metalloproteinase 2
Tissue Inhibitor of Metalloproteinases - metabolism
Tissues
Tuberculosis
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - enzymology
Tuberculosis, Pulmonary - metabolism
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Summary:Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum conversion. Induced sputum was collected from 68 TB patients and 69 controls in a cross-sectional study. MMPs concentrations were measured by Luminex array, TIMP concentrations by ELISA and were correlated with a disease severity score (TBscore). 46 TB patients were then studied longitudinally at the 2nd, 8th week and end of treatment. Sputum MMP-1,-2,-3,-8,-9 and TIMP-1 and -2 concentrations are increased in TB. Elevated MMP-1 and -3 concentrations are independently associated with higher TB severity scores (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061333