Phenotype and functions of natural killer cells in critically-ill septic patients

Natural killer cells, as a major source of interferon-γ, contribute to the amplification of the inflammatory response as well as to mortality during severe sepsis in animal models. We studied the phenotype and functions of circulating NK cells in critically-ill septic patients. Blood samples were ta...

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e50446-e50446
Main Authors: Forel, Jean-Marie, Chiche, Laurent, Thomas, Guillemette, Mancini, Julien, Farnarier, Catherine, Cognet, Céline, Guervilly, Christophe, Daumas, Aurélie, Vély, Frédéric, Xéridat, François, Vivier, Eric, Papazian, Laurent
Format: Article
Language:English
Subjects:
Aged
Animal models
Antibodies
B cells
Biological response modifiers
Biology
Blood
Blood circulation
CD3 antigen
CD56 antigen
Condition monitoring
Critical Illness
Cytokines
Cytokines - blood
Cytomegalovirus
Cytometry
Cytotoxicity
Degranulation
Female
Flow cytometry
Gene expression
Genetic aspects
Health aspects
Hospital patients
Humans
Infection
Inflammation
Inflammatory response
Interferon
Killer cells
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Lymphocyte Count
Lymphocyte receptors
Male
Medicine
Middle Aged
Natural killer cells
Nosocomial infections
Patients
Peripheral blood
Phenotype
Prospective Studies
Sepsis
Sepsis - blood
Sepsis - immunology
Sepsis - mortality
Septic shock
Severity of Illness Index
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - immunology
Systemic Inflammatory Response Syndrome - mortality
T cell receptors
Toxicity
γ-Interferon
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Summary:Natural killer cells, as a major source of interferon-γ, contribute to the amplification of the inflammatory response as well as to mortality during severe sepsis in animal models. We studied the phenotype and functions of circulating NK cells in critically-ill septic patients. Blood samples were taken
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0050446