Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat

Manipulations of the early environment are linked to long-lasting alterations of emotionality and social capabilities. Denial of rewarding mother-pup interactions in early life of rats could serve as model for child neglect. Negative consequences for social competence in later life, accompanied by c...

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Bibliographic Details
Published in:PloS one 2012-03, Vol.7 (3), p.e33793-e33793
Main Authors: Diamantopoulou, Anastasia, Raftogianni, Androniki, Stamatakis, Antonios, Alikaridis, Filaretos, Oitzl, Melly S, Stylianopoulou, Fotini
Format: Article
Language:English
Subjects:
Adolescents
Aggressive behavior
Aggressiveness
Amygdala
Animal models
Animals
Behavior
Behavior, Animal
Biochemistry
Biology
Brain
Brain - metabolism
Child abuse & neglect
Child development
Cocaine
Coping
Corticosterone - metabolism
Denial (Psychology)
Gene expression
Health sciences
Hippocampus
Humans
Impulsivity
Laboratories
Male
Medicine
Neurosciences
Newborn babies
Peers
Physiology
Posture
Prefrontal cortex
Psychopharmacology
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT1A - metabolism
Reinforcement
Reward
Rodents
Serotonin
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - metabolism
Serotonin S1 receptors
Serotonin transporter
Social aspects
Social Behavior
Stress, Psychological
Ultrasonic testing
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Summary:Manipulations of the early environment are linked to long-lasting alterations of emotionality and social capabilities. Denial of rewarding mother-pup interactions in early life of rats could serve as model for child neglect. Negative consequences for social competence in later life, accompanied by changes in the serotonergic system would be expected. In contrast, rewarding mother-pup contact should promote adequate social abilities. Male Wistar rats trained in a T-maze during postnatal days 10-13 under denial (DER) or permission (RER) of maternal contact were tested for play behavior in adolescence and for coping with defeat in adulthood. We estimated serotonin (5-HT) levels in the brain under basal conditions and following defeat, as well as serotonin receptor 1A (5-HT1A) and serotonin transporter (SERT) expression. DER rats exhibited increased aggressive-like play behavior in adolescence (i.e. increased nape attacks, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0033793