Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare group of tumors with a wide spectrum of clinical behavior. However, there are no known clinically relevant biomarkers to predict metastasis. To investigate differential gene expression signatures of metastatic vs non-metastatic NETs, w...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2012-04, Vol.7 (4), p.e34456-e34456
Main Authors: Lee, Jeeyun, Sung, Chang Ohk, Lee, Eui J, Do, In-Gu, Kim, Hee-Cheol, Yoon, Seong Hyeon, Lee, Woo Yong, Chun, Ho Kyung, Kim, Kyoung-Mee, Park, Young Suk
Format: Article
Language:English
Subjects:
Adult
Aged
Ataxia telangiectasia mutated protein
Ataxia Telangiectasia Mutated Proteins
Biology
Biomarkers
Breast cancer
Cancer metastasis
Cell cycle
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell growth
Cell Proliferation
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Experimental design
Female
Gene expression
Gene Expression Profiling
Genes
Hematology
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Lymphoma
Male
Medical research
Medicine
Metastases
Metastasis
Middle Aged
Mutation
Neuroendocrine tumors
Neuroendocrine Tumors - metabolism
Neuroendocrine Tumors - secondary
Pathology
Patients
Phosphorylation
Polymerase chain reaction
Protein folding
Protein Serine-Threonine Kinases - genetics
Protein Serine-Threonine Kinases - metabolism
Real-Time Polymerase Chain Reaction
Retrospective Studies
Review boards
RNA
Surgery
Transcription, Genetic
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare group of tumors with a wide spectrum of clinical behavior. However, there are no known clinically relevant biomarkers to predict metastasis. To investigate differential gene expression signatures of metastatic vs non-metastatic NETs, we studied cell cycle regulatory genes in 19 metastatic and 22 non-metastatic colorectal NETs by PCR arrays. Immunohistochemistry (IHC) and quantitative real-time RT-PCR were performed to verify the results and another set of 38 GEP-NETs were further studied for validation. We first delineated six candidate genes for metastasis including ATM, CCND2, RBL2, CDKN3, CCNB1, and GTSE1. ATM was negatively correlated with metastatic NETs (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0034456