Response of retinal blood flow to systemic hyperoxia as measured with dual-beam bidirectional Doppler Fourier-domain optical coherence tomography

There is a long-standing interest in the study of retinal blood flow in humans. In the recent years techniques have been established to measure retinal perfusion based on optical coherence tomography (OCT). In the present study we used a technique called dual-beam bidirectional Doppler Fourier-domai...

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Bibliographic Details
Published in:PloS one 2012-09, Vol.7 (9), p.e45876-e45876
Main Authors: Werkmeister, René M, Palkovits, Stefan, Told, Reinhard, Gröschl, Martin, Leitgeb, Rainer A, Garhöfer, Gerhard, Schmetterer, Leopold
Format: Article
Language:English
Subjects:
Adult
Algorithms
Biology
Biomedical engineering
Blood flow
Blood Flow Velocity
Coherence length
Diabetes
Diabetic retinopathy
Engineering
Erythrocytes
Fourier Analysis
Glaucoma
Health physics
Humans
Hyperoxia
Hyperoxia - physiopathology
Laser beams
Laser doppler velocimeters
Lasers
Medical imaging
Medicine
Optic nerve
Optical Coherence Tomography
Optical tomography
Oxygen
Oxygen - pharmacology
Oxygen breathing
Perfusion
Pharmacology
Physics
Physiological aspects
Red blood cells
Respiration
Retina
Retinal Vessels - metabolism
Retinal Vessels - physiology
Tomography, Optical Coherence
Vasoconstriction - drug effects
Velocimetry
Velocity
Velocity measurement
Young Adult
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Summary:There is a long-standing interest in the study of retinal blood flow in humans. In the recent years techniques have been established to measure retinal perfusion based on optical coherence tomography (OCT). In the present study we used a technique called dual-beam bidirectional Doppler Fourier-domain optical coherence tomography (FD-OCT) to characterize the effects of 100% oxygen breathing on retinal blood flow. These data were compared to data obtained with a laser Doppler velocimeter (LDV). 10 healthy subjects were studied on 2 study days. On one study day the effect of 100% oxygen breathing on retinal blood velocities was studied using dual-beam bidirectional Doppler FD-OCT. On the second study day the effect of 100% oxygen breathing on retinal blood velocities was assessed by laser Doppler velocimetry (LDV). Retinal vessel diameters were measured on both study days using a commercially available Dynamic Vessel Analyzer. Retinal blood flow was calculated based on retinal vessel diameters and red blood cell velocity. As expected, breathing of pure oxygen induced a pronounced reduction in retinal vessel diameters, retinal blood velocities and retinal blood flow on both study days (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0045876