The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial

• Published in: PloS one 2013-04, Vol.8 (4), p.e62744-e62744
• Main Authors: Lin, Ting-Yu, Lo, Yu-Lun, Hsieh, Chung-Hsing, Ni, Yung-Lun, Wang, Tsai-Yu, Lin, Horng-Chyuan, Wang, Chun-Hua, Yu, Chih-Teng, Kuo, Han-Pin
• Format: Article
• Language: English
• Subjects: Adjustment; Aged; Analysis; Anesthesia; Anesthetics, Intravenous - administration & dosage; Brain; Bronchoscopes - adverse effects; Bronchoscopy; Complications; Conscious Sedation - adverse effects; Conscious Sedation - methods; Consciousness; Endoscopy; Feasibility studies; Female; Hospitals; Humans; Hypotension; Hypotension - etiology; Hypoxemia; Hypoxia - etiology; Infusion; Infusions, Intravenous; Intensive care; Male; Medicine; Middle Aged; Narcotics; Outcome Assessment (Health Care); Oxyhemoglobin; Patients; Pharmacokinetics; Pharmacology; Phenols (Class of compounds); Physicians; Propofol; Propofol - administration & dosage; Randomization; Recovery; Recovery time; Respiration; Statistical analysis; Titration; Ventilators
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0062744

Target-controlled infusion (TCI) provides precise pharmacokinetic control of propofol concentration in the effect-site (Ce), eg. brain. This pilot study aims to evaluate the feasibility and optimal TCI regimen for flexible bronchoscopy (FB) sedation. After alfentanil bolus, initial induction Ce of propofol was targeted at 2 μg/ml. Patients were randomized into three titration groups (i.e., by 0.5, 0.2 and 0.1 μg/ml, respectively) to maintain stable sedation levels and vital signs. Adverse events, frequency of adjustments, drug doses, and induction and recovery times were recorded. The study was closed early due to significantly severe hypoxemia events (oxyhemoglobin saturation