Glycosylated hemoglobin and albumin-corrected fructosamine are good indicators for glycemic control in peritoneal dialysis patients

Diabetes mellitus (DM) is the most common cause of end-stage renal disease and is an important risk factor for morbidity and mortality after dialysis. However, glycemic control among such patients is difficult to assess. The present study examined glycemic control parameters and observed glucose var...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e57762-e57762
Main Authors: Lee, Szu-Ying, Chen, Yin-Cheng, Tsai, I-Chieh, Yen, Chung-Jen, Chueh, Shu-Neng, Chuang, Hsueh-Fang, Wu, Hon-Yen, Chiang, Chih-Kang, Cheng, Hui-Teng, Hung, Kuan-Yu, Huang, Jenq-Wen
Format: Article
Language:English
Subjects:
Aged
Albumin
Anemia
Blood Glucose - analysis
Care and treatment
Continuous ambulatory peritoneal dialysis
Correlation analysis
Data collection
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - therapy
Dialysis
Dialysis Solutions - administration & dosage
Dialysis Solutions - chemistry
Diaries
Drug dosages
End-stage renal disease
Extracellular Fluid - chemistry
Fasting
Female
Fructosamine - analysis
Glucans - administration & dosage
Glucans - chemistry
Glucose
Glucose - administration & dosage
Glucose - chemistry
Glucose metabolism
Glucose monitoring
Glycated Hemoglobin A - analysis
Health aspects
Health risks
Hemoglobin
Hospitals
Humans
Internal medicine
Kidney diseases
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Kidney transplantation
Male
Medicine
Metabolism
Middle Aged
Monitoring systems
Monitoring, Physiologic
Morbidity
Patient outcomes
Patients
Peritoneal dialysis
Peritoneal Dialysis, Continuous Ambulatory - standards
Peritoneum
Refilling
Risk factors
Serum Albumin - analysis
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Summary:Diabetes mellitus (DM) is the most common cause of end-stage renal disease and is an important risk factor for morbidity and mortality after dialysis. However, glycemic control among such patients is difficult to assess. The present study examined glycemic control parameters and observed glucose variation after refilling different kinds of fresh dialysate in peritoneal dialysis (PD) patients. A total of 25 DM PD patients were recruited, and continuous glucose monitoring system (CGMS) was applied to measure interstitial fluid (ISF) glucose levels at 5-min intervals for 3 days. Patients filled out diet and PD fluid exchange diaries. The records measured with CGMS were analyzed and correlated with other glycemic control parameters such as fructosamine, albumin-corrected fructosamine (AlbF), glycosylated hemoglobin (HbA1c), and glycated albumin levels. There were significant correlations between mean ISF glucose and fructosamine (r = 0.45, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057762