Natural killer cell function, an important target for infection and tumor protection, is impaired in type 2 diabetes

Patients with Type 2 diabetes (T2D) are highly susceptible to infection and have an increased incidence of some tumors, possibly due to immune system dysfunction. In the innate cellular immune system, Natural Killer (NK) lymphocytes are important effectors responsible for controlling infections and...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e62418-e62418
Main Authors: Berrou, Jeannig, Fougeray, Sophie, Venot, Marion, Chardiny, Victor, Gautier, Jean-François, Dulphy, Nicolas, Toubert, Antoine, Peraldi, Marie-Noëlle
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial infections
Biology
Blood donation
Blood donors
Comparative analysis
Complications
Defects
Degranulation
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - metabolism
Diabetics
Diseases
Endoplasmic reticulum
Endoplasmic Reticulum Stress - immunology
Female
Glycosylated hemoglobin
Health aspects
Humans
Hyperglycemia
Hyperglycemia - immunology
Immune system
Infection control
Infections
Infections - immunology
Interleukin 15
Killer cells
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinases
Ligands
Lymphocytes
Male
Medicine
Middle Aged
Natural Cytotoxicity Triggering Receptor 1 - genetics
Natural Cytotoxicity Triggering Receptor 1 - metabolism
Natural killer cells
Neoplasms - immunology
NK Cell Lectin-Like Receptor Subfamily K - genetics
NK Cell Lectin-Like Receptor Subfamily K - metabolism
NKG2 antigen
Oxidative stress
Patients
Phenotype
Protein folding
Proteins
Receptors
Signal transduction
Transcription, Genetic - immunology
Transplants & implants
Tumors
Tunicamycin
Type 2 diabetes
Viral infections
Young Adult
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Summary:Patients with Type 2 diabetes (T2D) are highly susceptible to infection and have an increased incidence of some tumors, possibly due to immune system dysfunction. In the innate cellular immune system, Natural Killer (NK) lymphocytes are important effectors responsible for controlling infections and combating tumor development. We analyzed NK cell subsets in 51 patients with long-standing T2D. Compared with healthy blood donors, diabetic patients showed a profound decrease in both NKG2D-positive NK cells (44% vs. 55.5%, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0062418