Association of genetic markers in the BCL-2 family of apoptosis-related genes with endometrial cancer risk in a Chinese population

In vitro studies have demonstrated the role of the BCL-2 family of genes in endometrial carcinogenesis. The role of genetic variants in BCL-2 genes and their interactions with non-genetic factors in the development of endometrial cancer has not been investigated in epidemiological studies. We examin...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e60915
Main Authors: Dorjgochoo, Tsogzolmaa, Xiang, Yong-Bing, Long, Jirong, Shi, Jiajun, Deming, Sandra, Xu, Wang-Hong, Cai, Hui, Cheng, Jiarong, Cai, Qiuyin, Zheng, Wei, Shu, Xiao-Ou
Format: Article
Language:English
Subjects:
Adult
Aged
Apoptosis
Apoptosis - genetics
Asian Continental Ancestry Group - genetics
Bax protein
Bcl-2 protein
Biology
Cancer
Cancer genetics
Cancer research
Carcinogenesis
Carcinogens
Case-Control Studies
Demographics
Development and progression
Endometrial cancer
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Endometrium
Epidemiology
Female
Genes
Genetic aspects
Genetic diversity
Genetic factors
Genetic markers
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Genetic variance
Health aspects
Health risk assessment
Health risks
Hormone replacement therapy
Humans
Medicine
Middle Aged
Patients
Physicians
Polymorphism, Single Nucleotide
Population studies
Proto-Oncogene Proteins c-bcl-2 - genetics
Risk analysis
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Tagging
Uterine cancer
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Summary:In vitro studies have demonstrated the role of the BCL-2 family of genes in endometrial carcinogenesis. The role of genetic variants in BCL-2 genes and their interactions with non-genetic factors in the development of endometrial cancer has not been investigated in epidemiological studies. We examined the relationship between BCL-2 gene family variants and endometrial cancer risk among 1,028 patients and 1,922 age-matched community controls from Shanghai, China. We also investigated possible interactions between genetic variants and established risk factors (demographic, lifestyle and clinical). Individuals were genotyped for 86 tagging single nucleotide polymorphisms (SNPs) in the BCL2, BAX, BAD and BAK1 genes. Significant associations with endometrial cancer risk were found for 9 SNPs in the BCL2 gene (P trend
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060915