Studying gene expression system regulation at the program level

Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e61324-e61324
Main Author: Alter, Mark D
Format: Article
Language:English
Subjects:
Algorithms
Alzheimer's disease
Autism
Biology
Bipolar disorder
Cocaine
Epigenetics
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Genes
Genetic research
Genomes
Humans
Interleukin-2 - pharmacology
Interneurons - cytology
Interneurons - metabolism
Mathematics
Medical treatment
Neurosciences
Oligonucleotide Array Sequence Analysis
Principal Component Analysis
Schizophrenia
Systems Biology
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Summary:Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological understanding. Yet, the best way to relate this immense amount of information to biological outcomes is far from clear. Here, a novel approach to gene expression systems research is presented that focuses on understanding gene expression systems at the level of gene expression program regulation. It is suggested that such an approach has important advantages over current techniques and may provide novel insights into how gene expression systems are regulated to shape biological outcomes such as the development of disease or response to treatment.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061324