Incidence and associated factors of HIV drug resistance in Chinese HIV-infected patients receiving antiretroviral treatment

• Published in: PloS one 2013-04, Vol.8 (4), p.e62408-e62408
• Main Authors: Xing, Hui, Wang, Xia, Liao, Lingjie, Ma, Yanling, Su, Bin, Fu, Jihua, He, Jianmei, Chen, Lin, Pan, Xiaohong, Dong, Yonghui, Liu, Wei, Hsi, Jenny H, Yang, Liting, Ruan, Yuhua, Shao, Yiming
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; CD4 antigen; CD4 Lymphocyte Count; Cell number; China - epidemiology; Cohort Studies; Developed countries; Didanosine; Disease prevention; Doctors; Drug resistance; Drug Resistance, Viral; Female; Genotyping; Highly active antiretroviral therapy; HIV; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV-1 - genetics; HIV-1 - isolation & purification; Human immunodeficiency virus; Humans; Incidence; Lymphocytes T; Male; Medical personnel; Medicine; Mutation; Patients; Physicians; Regression analysis; Resistance factors; Ribonucleic acid; RNA; Viral Load
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0062408

A critical indicator of the future success of highly active antiretroviral therapy (HAART) is the incidence of HIV drug resistance, which has not been studied in China on the national scale. HIV drug resistance baseline survey was conducted in the eight provinces with the largest numbers of patients on HAART in 2009, and a prospective cohort study with 12-month follow-up was completed in 2010. Patients completed an interviewer-administrated questionnaire and provided blood for CD4+ T-lymphocyte count (CD4 count), HIV viral load (VL), and HIV drug resistance genotyping. Factors associated with incidence of HIVDR were identified by Cox regression analysis. The overall prevalence of HIV RNA ≥ 1000 copies/ml and HIVDR at baseline was 12.4% and 5.6%, respectively. Incidence of HIVDR in the one year follow-up was 3.5 per 100 person years. Independently associated factors were started treatment with a didanosine-based regimen, received care at township hospital or village clinic, low baseline CD4 counts, and high baseline VL. The incidence of HIVDR in China was higher than that of some developed countries. China urgently needs to provide comprehensive education and training to doctors at village clinics and township hospitals to improve quality community-based care and treatment.