Exploratory analysis on the use of statins with or without n-3 PUFA and major events in patients discharged for acute myocardial infarction: an observational retrospective study

Combined treatment (CT) with statins and polyunsaturated fatty acids (n-3 PUFA) resulted in a reduction of death and major cardiovascular events when administered after a myocardial infarction (MI). However, recent data suggests that CT may be ineffective because patients are currently treated aggre...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e62772-e62772
Main Authors: Macchia, Alejandro, Romero, Marilena, D'Ettorre, Antonio, Tognoni, Gianni, Mariani, Javier
Format: Article
Language:English
Subjects:
Aged
Analysis
Atorvastatin Calcium
Cardiac patients
Cardiovascular agents
Care and treatment
Chronic obstructive pulmonary disease
Combined treatment
Diabetes
Drug Therapy, Combination
Failure analysis
Fatty acids
Fatty Acids, Omega-3 - therapeutic use
Female
Fibrillation
Fish oils
Health aspects
Heart
Heart attack
Heart attacks
Heart diseases
Heart failure
Heptanoic Acids - therapeutic use
Hospitals
Humans
Kaplan-Meier Estimate
Laboratories
Male
Matched-Pair Analysis
Medical research
Medicine
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - mortality
Myocardial Infarction - prevention & control
Patients
Polyunsaturated fatty acids
Pyrroles - therapeutic use
Retrospective Studies
Sensitivity and Specificity
Simvastatin - therapeutic use
Statins
Statistical analysis
Studies
Survival
Synergism
Treatment Outcome
Unsaturated fatty acids
Vital statistics
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Summary:Combined treatment (CT) with statins and polyunsaturated fatty acids (n-3 PUFA) resulted in a reduction of death and major cardiovascular events when administered after a myocardial infarction (MI). However, recent data suggests that CT may be ineffective because patients are currently treated aggressively and the risk may not be further decreased. We aimed to study the prevalence and the results on major outcomes with CT among patients discharged with a MI in Italy. Retrospective cohort study that used linked hospital discharge, prescription databases and vital statistics containing information on 14,704 patients who were discharged for MI between 1/2003 and 12/2003 in 117 hospitals in Italy. All analyses were time-dependent and adjusted for major confounders. Sensibility and paired matched analysis were conducted to further verify main results. A total of 11,532 (78.4%) filled a prescription for a statin. Of these, 4302 (37.3%) were on CT. There were 45,528 patients/years of follow-up. As compared with statins alone, CT was associated with an adjusted higher survival rate (HR = 0.59 [0.52-0.66], p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0062772