Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors

The main objective of this study was to assess cardiac death (CD) kidney grafts before transplantation to determine whether blood oxygen level-dependent (BOLD) and diffusion MRI techniques can predict damage to these grafts after transplantation. We assessed CD kidney tissue by BOLD and diffusion MR...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e63573
Main Authors: Kaimori, Jun-Ya, Iwai, Satomi, Hatanaka, Masaki, Teratani, Takumi, Obi, Yoshitsugu, Tsuda, Hidetoshi, Isaka, Yoshitaka, Yokawa, Takashi, Kuroda, Kagayaki, Ichimaru, Naotsugu, Okumi, Masayoshi, Yazawa, Koji, Rakugi, Hiromi, Nonomura, Norio, Takahara, Shiro, Kobayashi, Eiji
Format: Article
Language:English
Subjects:
Adenosine
Allopurinol
Animals
Blood vessels
Damage assessment
Death
Diffusion
Diffusion coefficient
Edema
Erythrocytes - metabolism
Gene expression
Gene Expression Profiling
Geriatrics
Glutathione
Grafting
Grafts
Heart
Heart diseases
Information science
Insulin
Ischemia
Kidney Cortex - metabolism
Kidney Medulla - metabolism
Kidney Medulla - pathology
Kidney Transplantation
Kidneys
Magnetic resonance
Magnetic Resonance Imaging
Medical technology
Medicine
Mortality
Nephrology
Neuroimaging
NMR
Nuclear magnetic resonance
Organ Preservation Solutions
Oxygen
Oxygen - blood
Pathogenesis
Perfusion
Permeability
Raffinose
Rats
Rats, Inbred Lew
Rodents
t-Plasminogen activator
Tissue plasminogen activator
Transplantation
Transplants & implants
University graduates
Urology
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Summary:The main objective of this study was to assess cardiac death (CD) kidney grafts before transplantation to determine whether blood oxygen level-dependent (BOLD) and diffusion MRI techniques can predict damage to these grafts after transplantation. We assessed CD kidney tissue by BOLD and diffusion MRI. We also examined pathological and gene expression changes in CD kidney grafts before and after transplantation. Although there was significantly more red cell congestion (RCC) in the inner stripe of the outer medulla (IS) in both 1 h after cardiac death (CD1h) and CD2h kidneys destined for grafts before transplantation compared with CD0h (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063573