Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population

We investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population. We evaluated twelve tagging single-nucleotide polymorphisms (tSNPs) of the PNPLA3 gene in a frequency matched...

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Bibliographic Details
Published in:PloS one 2012-11, Vol.7 (11), p.e50256-e50256
Main Authors: Peng, Xian-E, Wu, Yun-Li, Lin, Shao-Wei, Lu, Qing-Qing, Hu, Zhi-Jian, Lin, Xu
Format: Article
Language:English
Subjects:
Abdomen
Adipocytes
Adult
Alleles
Asian Continental Ancestry Group
Association analysis
Biology
Cancer
Case-Control Studies
Development and progression
Diabetes
Disease susceptibility
Drinking behavior
Education
Enzymes
Epidemiology
Ethnicity
Fatty liver
Fatty Liver - complications
Fatty Liver - enzymology
Fatty Liver - ethnology
Fatty Liver - genetics
Female
Gastroenterology
Genes
Genetic aspects
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genomes
Genotypes
Haplotypes
Health care
Health risks
Hepatitis
Hospitals
Humans
Hypertension
Hypertension - complications
Hypertension - enzymology
Hypertension - ethnology
Hypertension - genetics
Hypertriglyceridemia
Hypertriglyceridemia - complications
Hypertriglyceridemia - enzymology
Hypertriglyceridemia - ethnology
Hypertriglyceridemia - genetics
Insulin resistance
Laboratories
Lipase - genetics
Lipase - metabolism
Liver
Liver - enzymology
Liver - pathology
Liver diseases
Male
Medicine
Membrane Proteins - genetics
Membrane Proteins - metabolism
Middle Aged
Non-alcoholic Fatty Liver Disease
Obesity
Obesity - complications
Obesity - enzymology
Obesity - ethnology
Obesity - genetics
Phospholipase
Polymorphism, Single Nucleotide
Population
Public health
Regression analysis
Risk
Rodents
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical analysis
Tagging
Tea
Triglycerides
Ultrasonic imaging
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Summary:We investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population. We evaluated twelve tagging single-nucleotide polymorphisms (tSNPs) of the PNPLA3 gene in a frequency matched case-control study from Fuzhou city of China (553 cases, 553 controls). In the multivariate logistic regression analysis, the rs738409 GG or GC, and rs139051 TT genotypes were found to be associated with increased risk of NAFLD, and a significant trend of increased risk with increasing numbers of risk genotype was observed in the cumulative effect analysis of these single nucleotide polymorphisms. Furthermore, haplotype association analysis showed that, compared with the most common haplotype, the CAAGAATGCGTG and CGAAGGTGTCCG haplotypes conferred a statistically significant increased risk for NAFLD, while the CGGGAACCCGCG haplotype decreased the risk of NAFLD. Moreover, rs738409 C>G appeared to have a multiplicative joint effect with tea drinking (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0050256