Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study

We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adol...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e57454-e57454
Main Authors: Dangardt, Frida, Chen, Yun, Berggren, Krister, Osika, Walter, Friberg, Peter
Format: Article
Language:English
Subjects:
Adolescent
Adolescent obesity
Adolescents
all-cause
Arteries
Blood Flow Velocity - physiology
Blood pressure
Body mass
Body mass index
cardiovascular risk-factors
Carotid Arteries - pathology
Carotid artery
Case-Control Studies
childhood
Childhood obesity
Children
Comparative analysis
Follow-Up Studies
Fysiologi
Health risk assessment
Humans
Longitudinal Studies
Medicine
Obesity
Obesity - pathology
Physiology
Prospective Studies
pulse-wave velocity
Stiffening
Stiffness
Teenagers
Tunica Intima - pathology
Ultrasound
Vascular Stiffness - physiology
Veins & arteries
wall thickness
Wave velocity
young finns
Youth
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV) and vascular morphology of the radial (RA) and dorsal pedal arteries (DPA) were examined in obese adolescents compared to lean subjects in a 5-year follow-up study. A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old) and follow-up studies. PWV was measured by tonometer (SphygmoCor®) and recorded at RA and carotid artery, respectively. Intima thickness (IT), intima-media thickness (IMT) and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™). Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01). Diastolic blood pressure (DBP) increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009). BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057454